Results 61 to 70 of about 9,142,990 (286)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Significance of youth and sports in Ukraine backup for the education of the younger generation

Pedagogics, Psychology, Medical-Biological Problems of Physical Training and Sports, 2014
Purpose: determine the social significance and especially the development of youth and sports reserve in Ukraine. Material : a questionnaire survey of 50 experts in the sphere of physical culture and sports.
N. V. Tikhonova
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

GAME LEVELS AND DECLARATIVE KNOWLEDGE IN YOUNG BASKETBALL PLAYERS FROM CEARÁ STATE [Niveles de Juego y conocimiento declarativo en jóvenes jugadores de baloncesto del Estado de Ceará]

E-balonmano.com: Revista de Ciencias del Deporte, 2019
Basketball is one of the most practiced sports in the state of Ceará, in the school environment. The traditional method is the most used among teachers and coaches.
Ítalo Nunes Braga, Ricardo Hugo Gonzalez   +1 more
doaj  

Matching school sports managers’ job demands with resources for optimal performance in Nigeria

Sport TK
School sports are beneficial to schools, communities and society as a whole in that they can prevent delinquent behaviours, force commitment to rules, promote social control and teach societal/school values, among others.
Ufuoma Vivian Arenyeka, Dorah Ataphia Akporehe, Ochuko Eric Nabofa   +2 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Dynamics and Value of School Sport in the context of La Salle Manaus School Management

Revista Intercontinental de Gestão Desportiva, 2020
Knowledge about Management is increasingly important in society, which is composed of organizations that are increasingly complex and constantly changing.
Lúcia Paiva, Maria José Carvalho, Paula Batista   +2 more
doaj  

SCHOOL SPORTS ACCORDING TO THE OWNERSHIP OF THE SCHOOLS

Tendencias Pedagógicas, 2015
In this research, sport is going to be looked into from an educational perspective. We will specifically focus on sports at school. In order to develop sporting activities at school, with all their implied characteristics, it is necessary that they be organized and developed by qualified professionals. Recently, a research has been made and the purpose
María Espada Mateos, Antonio Campos Izquierdo, María Dolores González Rivera, José Carlos Calero Cano   +3 more
openaire   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source