Results 201 to 210 of about 781,987 (294)

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

School Attendance Pre- and Post-Pandemic in Adolescents with Chronic Pain. [PDF]

Children (Basel)
Berry JR, Sim L, Harbeck-Weber C, Weiss K.   +3 more
europepmc   +1 more source

Schools and Schooling

, 2017
openaire   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Clustering of hypertension and clustering of diabetes at the household level and variations in disease awareness within households in India: findings from a nationally representative household survey. [PDF]

BMJ Glob Health
Pedgaonkar S, Kumar S, Meitei WB, Chaudhary A, Singh A, Singh A.   +5 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Corrigendum: Renewed occurrence of schooling scalloped hammerhead (Sphyrna lewini) and of great hammerhead (S. mokarran) sharks in the Cayman Islands

Frontiers in Marine Science
Mauvis Gore, Johanna Kohler, Rupert Ormond, Austin Gallagher, Teresa Fernandes, Timothy Austin, Christy Pattengill-Semmens   +6 more
doaj   +1 more source

Digital Exclusion Among People Experiencing Homelessness and Residents of Urban Communities in Brazil: Cross-Sectional Study.

JMIR Public Health Surveill
Tártaro AF, Gomes D, Berra TZ, Tavares RBV, Alves YM, Ferezin LP, Ramos ACV, Zini N, Pelodan MEP, Popolin MAP, Arcêncio RA.   +10 more
europepmc   +1 more source

Everyday discrimination among middle-aged and older adults in India: a multilevel cross-sectional analysis from the Longitudinal Ageing Study in India. [PDF]

Sci Rep
Sadhu R, Ko S, Subramanian SV, Kim R.
europepmc   +1 more source