Results 121 to 130 of about 48,194 (288)

Multi‐Shank 1024 Channels Active SiNAPS Probe for Large Multi‐Regional Topographical Electrophysiological Mapping of Neural Dynamics

Advanced Science, EarlyView.
This research article introduces a novel CMOS neural probe with 1024 channels distributed across eight shanks. The SiNAPS probe allows for the simultaneous recording of both local field potentials and action potentials in large brain areas. The probe's design allows for detailed mapping and linking neural dynamics and population unit activity, as ...
Gian Nicola Angotzi, Mihály Vöröslakos, Nikolas Perentos, Joao Filipe Ribeiro, Matteo Vincenzi, Fabio Boi, Aziliz Lecomte, Gabor Orban, Andreas Genewsky, Gerrit Schwesig, Deren Aykan, György Buzsáki, Anton Sirota, Luca Berdondini   +13 more
wiley   +1 more source

Different coding characteristics between flight and freezing in dorsal periaqueductal gray of mice during exposure to innate threats

Animal Models and Experimental Medicine, Volume 5, Issue 6, Page 491-501, December 2022., 2022
Flight and freezing are two vital defensive behaviors in the process of avoiding natural enemies in mice. We investigated the neural activity in dPAG nuclei of mice under two defensive behaviors, and found different coding features between flight and freezing behaviors. Abstract Background Flight and freezing are two vital defensive behaviors that mice
Denghui Liu, Shouhao Li, Liqing Ren, Xinyu Liu, Xiaoyuan Li, Zhenlong Wang   +5 more
wiley   +1 more source

Masked Latent Transformer with the Random Masking Ratio to Advance the Diagnosis of Dental Fluorosis [PDF]

arXiv
Dental fluorosis is a chronic disease caused by long-term overconsumption of fluoride, which leads to changes in the appearance of tooth enamel. It is an important basis for early non-invasive diagnosis of endemic fluorosis. However, even dental professionals may not be able to accurately distinguish dental fluorosis and its severity based on tooth ...
arxiv  

Inhibition of Ferroptosis Delays Aging and Extends Healthspan Across Multiple Species

Advanced Science, EarlyView.
This study identifies ferroptosis as a key driver of cellular senescence, with its inhibition delaying aging and extending healthspan across species. During senescence, ferroptosis worsens, increasing oxidative stress and lipid peroxidation, which accelerate aging.
Hai‐Jun Fu, Xing‐Yue Zhou, Da‐Lian Qin, Qan Qiao, Qiao‐Zhi Wang, Shi‐Ying Li, Yun‐Fei Zhu, Ya‐Ping Li, Jiang‐Min Zhou, Hui Cai, Fei‐Hong Huang, Lu Yu, Long Wang, An‐Guo Wu, Jian‐Ming Wu, Xiao‐Gang Zhou   +15 more
wiley   +1 more source

Single‐Cell Sequencing‐Guided Annotation of Rare Tumor Cells for Deep Learning‐Based Cytopathologic Diagnosis of Early Lung Cancer

Advanced Science, EarlyView.
This study presents an innovative method to generate high‐quality, objectively annotated cytology datasets without relying on expert involvement. Large‐scale single‐cell DNA sequencing is used as an objective ground truth of cell annotation for generating an accurate, unbiased dataset of exfoliated tumor cells from bronchoalveolar lavage cytology ...
Yichun Zhao, Ruoran Qiu, Zhuo Wang, Yunyun Li, Xu Yang, Yanlin Li, Xiaohan Shen, Yun Liu, Ziqiang Chen, Qihan You, Qihui Shi   +10 more
wiley   +1 more source

Regulation of PVT‐CeA Circuit in Deoxynivalenol‐Induced Anorexia and Aversive‐Like Emotions

Advanced Science, EarlyView.
The study investigates Deoxynivalenol (DON) effects on feeding and emotions, focusing on the central amygdala (CeA). Acute DON exposure reduces food intake and alters behavior, linked to CeAGABA neuron activity and PVT‐CeA connectivity. Manipulating CeAGABA neurons and using SCN10A antagonist A‐803467 alleviate DON's effects, offering potential ...
Liu‐Nan Yang, Mingmeng Tang, Andreas K. Nüssler, Liegang Liu, Wei Yang   +4 more
wiley   +1 more source

Outermost Cationic Surface Charge of Layer‐by‐Layer Films Prevents Endothelial Cells Migration for Cell Compartmentalization in Three‐Dimensional Tissues

Advanced Science, EarlyView.
A nanometer‐sized artificial basement membrane (A‐BM) is developed to replicate the barrier functions of the basement membrane and prevent cell migration. It is demonstrated that the outermost cationic surface charge of nanofilms can effectively inhibit endothelial cell migration and sprouting, allowing for the construction of 3D patterned vascular ...
Jinfeng Zeng, Sven Heilig, Matthias Ryma, Jürgen Groll, Congju Li, Michiya Matsusaki   +5 more
wiley   +1 more source

Improving Dental Diagnostics: Enhanced Convolution with Spatial Attention Mechanism [PDF]

arXiv
Deep learning has emerged as a transformative tool in healthcare, offering significant advancements in dental diagnostics by analyzing complex imaging data. This paper presents an enhanced ResNet50 architecture, integrated with the SimAM attention module, to address the challenge of limited contrast in dental images and optimize deep learning ...
arxiv  

Manipulation of Oxygen Tension in Damaged Regions via Hypoxia‐Induced IPN Hydrogel Microspheres for Intervertebral Disc Regeneration

Advanced Science, EarlyView.
A novel interpenetrating network hydrogel microsphere (NSC‐Exos@HIMS) is developed to manipulate oxygen tension in damaged regions and recruit endogenous stem cells. In vitro and in vivo results show that NSC‐Exos@HIMS maintains the hypoxia microenvironment for up to 5 days, which triggers nucleus pulposus cell‐like differentiation and enhanced ECM ...
Xingdie Zhou, Zhendong Lv, Zehao Chen, Yiming Xu, Chao Lin, Li Liu, Hao Chen, Bing Niu, Wenguo Cui, Yuhui Zhang   +9 more
wiley   +1 more source

Endostructural and periosteal growth of the human humerus

The Anatomical Record, Volume 306, Issue 1, Page 60-78, January 2023., 2023
Abstract The growth and development of long bones are of considerable interests in the fields of comparative anatomy and palaeoanthropology, as evolutionary changes and adaptations to specific physical activity patterns are expected to be revealed during bone ontogeny.
Thomas George O'Mahoney, Tristan Lowe, Andrew Timothy Chamberlain, William Irvin Sellers   +3 more
wiley   +1 more source