Results 111 to 120 of about 9,175,674 (404)
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Tackling poverty and disadvantage in schools: working with the community and other services [PDF]
, 2011 The link between disadvantage and educational underachievement is still strong. Most schools still fail to target support specifically at disadvantaged learners and only a few analyse data effectively enough to identify disadvantaged learners.
core
Making the Co-operative School a Challenge Alternative: Social Reproduction Theory Revisited [PDF]
, 2017 While co-operative schools are different, there are different kinds of different schools. This essay examines the type of alternative co-operative schools are, using distinctions Philip A. Woods draws from Maori philosophy of education.
David Backer
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
TAp63γ is the primary isoform of TP63 for tumor suppression but not development
Cell Death DiscoveryTP63 is expressed as TAp63 and ΔNp63 from the P1 and P2 promoters, respectively. While TAp63 and ΔNp63 are expressed as three TAp63α/β/γ and ΔNp63α/β/γ due to alternative splicing, only p63α (TA and ΔN) and p63γ (TA and ΔN) proteins are found to be ...
Xinbin Chen +9 more
doaj +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Languages at key stage 4 2009-2011 : evaluation of the impact of Languages Review recommendations : baseline findings from the first year of the evaluation [PDF]
, 2010 • Heads of language departments consider good teaching and support to be central to encouraging language uptake at KS4, and constraints of the options system to be the main barrier.
Filmer-Sankey, Caroline. +2 more
core
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Some inconvenient truths about education in Aotearoa-New Zealand [PDF]
, 2008 How does poverty affect New Zealand children’s schooling? Answers to this question generally revolve around three perspectives. First, it is argued that the children of families in poverty in New Zealand are disadvantaged in schools because of the level ...
Thrupp, Martin
core
COVID-19 Risk Management and Emotional Reactions to COVID-19 Among School Teachers in Denmark
, 2021 Kirsten Nabe‐Nielsen +3 more
openalex +2 more sources