Results 111 to 120 of about 5,153,183 (387)

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Effect of different noise reduction techniques and template matching parameters on markerless tumor tracking using dual‐energy imaging

Journal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022
Abstract Purpose To evaluate the impact of various noise reduction algorithms and template matching parameters on the accuracy of markerless tumor tracking (MTT) using dual‐energy (DE) imaging. Methods A Varian TrueBeam linear accelerator was used to acquire a series of alternating 60 and 120 kVp images (over a 180° arc) using fast kV switching, on ...
Mandeep Kaur, Peter Wagstaff, Hassan Mostafavi, Mathias Lehmann, Daniel Morf, Liangjia Zhu, Hyejoo Kang, Michal Walczak, Matthew M. Harkenrider, John C. Roeske   +9 more
wiley   +1 more source

TAp63γ is the primary isoform of TP63 for tumor suppression but not development

Cell Death Discovery
TP63 is expressed as TAp63 and ΔNp63 from the P1 and P2 promoters, respectively. While TAp63 and ΔNp63 are expressed as three TAp63α/β/γ and ΔNp63α/β/γ due to alternative splicing, only p63α (TA and ΔN) and p63γ (TA and ΔN) proteins are found to be ...
Xinbin Chen, Wenqiang Sun, Xiangmudong Kong, Xin Ming, Yanhong Zhang, Wensheng Yan, Shakur Mohibi, Mingyi Chen, Keith Mitchell, Jin Zhang   +9 more
doaj   +1 more source

The role of libraries of schools for excellence in science and technology in Egypt (STEM Egypt) in supporting ideas creativity for students and encouraging innovative industries

Cybrarians Journal
Libraries of STEM Schools in Egypt support creative ideas and invest the potential capabilities of students. Therefore, this study seeks to achieve a main goal, which is to study the role of STEM school libraries in Egypt in supporting the creative ...
Alaa Abdel Ghaffar, Rasha Rashdan
doaj   +1 more source

Incorporating Equity into the School Bus Scheduling Problem [PDF]

arXiv, 2018
We consider the school bus scheduling problem (SBSP) which simultaneously determines school bell times and route schedules. Often, the goal of the SBSP is to minimize the number of buses required by a school district. We extend a time-indexed integer programming model to incorporate additional considerations related to equity and efficiency. We seek to
arxiv  

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Twelve Months On: Navigating the Disparity Between Vision and Reality for Religious Education Teachers in Australian Catholic Schools

Paedagogia Christiana
This study builds on previous research exploring the formation needs and experiences of Early Career Teachers (ECT) in Catholic Schools in an Australian regional context, particularly concerning their understanding of Catholic identity and the teaching ...
Joan Lancaster, Kurt Challinor, Richard Rymarz   +2 more
doaj   +1 more source

A Cost-Minimizing Algorithm for School Choice [PDF]

arXiv, 2010
The school choice problem concerns the design and implementation of matching mechanisms that produce school assignments for students within a given public school district. In this note we define a simple student-optimal criterion that is not met by any previously employed mechanism in the school choice literature.
arxiv  

Families of Schools 2011: Black Country secondary schools [PDF]

, 2011
This is the 2011 edition of Families of Schools for the Black Country which is based on final 2010 data. The data presented allows users to compare the performance of their school against the performance of other Black Country schools with statistically ...

core  

The School Club, the School Garden, and Correlated School Activities [PDF]

The Elementary School Teacher, 1909
While at first thought there may seem to be little possible relation between the school club and the school garden, the former organized and conducted by the pupils of the upper elementary school to accomplish certain results which appeal to them as worthy of their efforts and which can be achieved only through co-operation, and the latter fast ...
openaire   +3 more sources