Results 141 to 150 of about 4,071,222 (306)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

How to increase participation and compliance in a national, school-based survey: strategies from the HBSC study 2018, 2022 and 2024 in Kalaallit Nunaat. [PDF]

Int J Circumpolar Health
Andersen MM, Nystrup K, Svartá DL, Larsen CVL, Niclasen B, Schnohr Svensson C.   +5 more
europepmc   +1 more source

Creating the Medical Schools of the Future.

Academic medicine : journal of the Association of American Medical Colleges, 2017
S. Skochelak, S. Stack
semanticscholar   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Neighborhood socioeconomic disadvantage and school stock inhaler utilization in a statewide program. [PDF]

Front Public Health
Reyes SM, Knitter A, Wan W, Gerald LB, Hardy PL, Pappalardo AA, Salem E, Weigley S, Volerman A.   +8 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

School mental health promotion in Indonesia: a quantitative survey from Surabaya. [PDF]

Front Psychol
Margaretha M, Azzopardi PS, Fisher J, Sawyer SM.   +3 more
europepmc   +1 more source

Effects of Probiotics in Pregnant Women with Gestational Diabetes Mellitus: An Overview of Systematic Reviews

International Journal of General Medicine
Huixia Ren,* Naijin Zhang,* Yonghui Li, Yingxiang Li, Mengyang Wang, Huaien Bu, Hongwu Wang School of Public Health, Tianjin University of Traditional Chinese Medicine, Tianjin, People’s Republic of China*These authors contributed
Ren H, Zhang N, Li Y, Li Y, Wang M, Bu H, Wang H   +6 more
doaj  

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

The impact of specialist resource centres on autistic pupils' experience of mainstream school. [PDF]

Autism
Cook A, Boddy A.
europepmc   +1 more source