Results 141 to 150 of about 9,175,674 (404)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
A Closer Look at the Charter School Movement: Charter Schools, Students, and Management Organizations, 2015-16 [PDF]
, 2016 Enrollment in charter public schools has grown by 250,000 students in the 2015-16 school year, and more than 400 new charter public schools have opened their doors, according to, A Closer Look at the Charter School Movement: Schools, Students, and ...
core
Maternal Lifestyle Factors and Fetal Macrosomia Risk: A Review
European Medical Journal Reproductive Health, 2016 Fetal macrosomia is associated with a number of health complications for both mother and infant in the immediate, short, and long-term. Maternal obesity and excessive gestational weight gain (GWG) have long been associated with fetal macrosomia, however ...
Kathy M. Redfern +2 more
doaj
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Faith Primary Schools: Better Schools or Better Pupils? [PDF]
We provide estimates of the effect of attending a Faith school on educational attainment progress during the Primary education phase in England. We argue that there are no credible instruments for Faith school attendance.
Olmo Silva, Steve Gibbons
core
School-based practicum and pre-service teachers' self-efficacy: Impact and challenges
, 2023 Awad Faek Altarawneh +3 more
openalex +2 more sources
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Careers 2020: options for future careers work in English schools. [PDF]
, 2012 Careers work in English schools has endured much turbulence recently. The government has now established a statutory duty on schools to secure provision, placing commissioning of careers advice and guidance in the hands of schools rather than local ...
Coiffait, Louis +3 more
core +1 more source