Results 161 to 170 of about 9,175,674 (404)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Inside Online Charter Schools [PDF]

, 2015
Online charter schools -- also known as virtual charters or cyber charters -- are publicly funded schools of choice that deliver student instruction via telecommunications.
Amanda Lee, Brian Gill, Claire Wulsin, Eric Grau, Holly Matulewicz, Lucas Walsh, Tess Kerwin, Veronica Severn   +7 more
core  

A Comparison of Demographic Diversity Between Orthopaedic Surgery Residents and ACGME Foot and Ankle Fellows From 2007 to 2022

Foot & Ankle Orthopaedics
Background: Academic medicine emphasizes the need to recruit a diverse workforce in graduate medical education. Orthopaedic surgery residency has demonstrated efforts to model program compositions with evolving US demographics.
Aditya Joshi BS, Andrew Kim BS, Nigel Hsu MD, Amiethab Aiyer MD, John M. Thompson MD   +4 more
doaj   +1 more source

Covid-19 school closures negatively impacted elementary-school students’ reading comprehension and reading fluency skills [PDF]

, 2023
Isabella Starling‐Alves, Guilherme Hirata, João Batista Araújo e Oliveira   +2 more
openalex   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Traditional Public School and Charter School Funding in Arkansas (UPDATED) [PDF]

, 2014
The existence and expansion of charter schools in Arkansas continue to be controversial. Proponents of charters argue that charter schools are unfairly burdened because they do not have access to local property tax revenue.
McKenzie, Sarah C., Ritter, Gary W.
core   +2 more sources

Promoting young people's health through drama and dance

Education in the North, 2008
Kerry Dalgetty, Julie Redman, Christopher Taylor   +2 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Guidance for hubs and schools: provision for children of critical workers and vulnerable children [PDF]

, 2020

core  

Teachers at faith schools in England and Wales : state of research [PDF]

, 2010
This study begins by distinguishing between three kinds of ‘faith schools’ (known as schools with a religious character) within England and Wales: faith schools that operate within the state-maintained sector and had their origin in voluntary church ...
Francis, Leslie J., Robbins, Mandy
core