Results 81 to 90 of about 4,071,222 (306)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

GPU accelerated 3-D ultrasonic flaw imaging using full waveforms sampling and processing technique

Nihon Kikai Gakkai ronbunshu, 2015
We develop a three dimensional (3-D) flaw imaging system using the full waveforms sampling and processing (FSAP) technique and an ultrasonic matrix array transducer.
Kazuyuki NAKAHATA, Takashi HORIGUCHI
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

TAp63γ is the primary isoform of TP63 for tumor suppression but not development

Cell Death Discovery
TP63 is expressed as TAp63 and ΔNp63 from the P1 and P2 promoters, respectively. While TAp63 and ΔNp63 are expressed as three TAp63α/β/γ and ΔNp63α/β/γ due to alternative splicing, only p63α (TA and ΔN) and p63γ (TA and ΔN) proteins are found to be ...
Xinbin Chen, Wenqiang Sun, Xiangmudong Kong, Xin Ming, Yanhong Zhang, Wensheng Yan, Shakur Mohibi, Mingyi Chen, Keith Mitchell, Jin Zhang   +9 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Twelve Months On: Navigating the Disparity Between Vision and Reality for Religious Education Teachers in Australian Catholic Schools

Paedagogia Christiana
This study builds on previous research exploring the formation needs and experiences of Early Career Teachers (ECT) in Catholic Schools in an Australian regional context, particularly concerning their understanding of Catholic identity and the teaching ...
Joan Lancaster, Kurt Challinor, Richard Rymarz   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Hydrogen Permeation Properties of Ternary Ni–BaCe_0.9Y_0.1O₃–Ce_0.9Gd_0.1O₂ Cermet Membranes

Ceramics
A ternary Ni–BaCe0.9Y0.1O3 (BCY)–Ce0.9Gd0.1O2 (GDC) cermet involving 40 vol% Ni was fabricated, and its hydrogen permeation characteristics were evaluated when the GDC volume fraction was varied from 0 to 30 vol%.
Yoshiteru Itagaki, Hiroyuki Mori, Takumi Matsubayashi, Hiromichi Aono   +3 more
doaj   +1 more source

School quality and school location [PDF]

, 2000
This paper presents a model of school choice with peer effects and scale economies within schools. Parents' perception of school quality depends on resources and on the characteristics of the student body. A network of local schools of uniform quality will be optimal, even though different households prefer different qualities.
openaire   +1 more source