Results 51 to 60 of about 5,162 (260)

EP300‐Mediated MTF1‐K218 Lactylation Buffers AR‐Driven Copper Overload to Suppress Cuproptosis in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
Androgen receptor (AR) drives copper accumulation in prostate cancer while inducing MTF1 to buffer copper toxicity. EP300‐mediated lactylation of MTF1 at K218 promotes its nuclear translocation and metallothionein expression, sequestering cytosolic copper and preventing mitochondrial cuproptosis.
Kai Li, Yong Wei, Yongshan Li, Yuxiang Dong, Jiancheng Lv, Mingzhi Yuan, Ao Shen, Fuyang Liu, Yetao Zhang, Youjian Li, Ruixi Yu, Yang Liu, Tong Zhao, Jun Wang, Kai Zhou, Zongyao Fan, Manning Wang, Jun Xu, Mulong Du, Min Gu, Bing Yao, Qingyi Zhu   +21 more
wiley   +1 more source

Challenges and Change: Integrating Grammar Teaching With Communicative Work in Senior High School EFL Classes

SAGE Open, 2017
This article reports a multiple case study that explores the potential impact of Japan’s national curriculum for senior high school English as a foreign language (EFL), specifically in relation to the integration of grammar teaching with communicative ...
Paul R. Underwood
doaj   +1 more source

IFI27 and BAX are Essential for GSDME‐Mediated Myeloma Cell Pyroptosis

Advanced Science, EarlyView.
The proposed model of GSDME‐mediated MM cell pyroptosis modulated by IFI27 and BAX. IFI27 is downregulated in MM cells. Upon pyroptotic stimulation, such as DOX or ETO treatment, IFI27 is induced, therefore liberating BAX from BCL‐2 ❶. BAX is then recruited to mitochondria and forms homo‐oligomeric channels in OMM, therefore leading to cytochrome C ...
Yaoli Cui, Yuening Sun, Ziyang Liu, Xuntao Lai, Yunshu Zhao, Yan'er Wang, Yuanming He, Fang Xu, Du Feng, Longlong Liu, Zhenqian Huang, Lijie Xing, Xinliang Mao   +12 more
wiley   +1 more source

A Preclinical Multifunctional Capsule Robot with Unified Diagnosis and Targeted Thermal Therapy for Gastrointestinal Diseases

Advanced Science, EarlyView.
A proof‐of‐concept multifunctional capsule robot integrates diagnostic imaging, magnetic navigation, wireless power transfer, and targeted thermotherapy for gastrointestinal applications. Magnetically guided positioning and stable wireless power enable localized thermal ablation, achieving controlled heating and high cell mortality in vitro.
Heng Zhang, Yichong Sun, Xiaoting Zhang, Chi‐Kwan Lee, Zheng Li, Yehui Li, Huarong Chen, Paul D. Mitcheson   +7 more
wiley   +1 more source

Japanese Buddhist journals as a means of supporting missionary activities in the late 19^th – early 20^th centuries

Японские исследования
In the late 19th – early 20th centuries, Japanese Buddhism was going through difficult times. Institutional crisis, loss of governmental support, competition with Shinto and Christianity, persecution caused by both political and social factors ...
E. O. Novoselova
doaj   +1 more source

Identifying Japanese students’ core spatial reasoning skills by solving 3D geometry problems: An exploration

Asian Journal for Mathematics Education, 2022
Taking the importance of spatial reasoning skills, this article aims to identify “core” spatial reasoning skills which are likely to contribute to successful problem-solving in three-dimensional (3D) geometry.
Taro Fujita, Yutaka Kondo, Hiroyuki Kumakura, Shinichi Miawaki, Susumu Kunimune, Kojiro Shojima   +5 more
doaj   +1 more source

Multifunctional Quantum Sensing Using Single Spins in a van der Waals Crystal

Advanced Science, EarlyView.
The work demonstrates a dual quantum sensing of temperature and magnetic field using spin‐complex quantum emitters in hexagonal boron nitride (hBN). Temperature sensing via zero‐phonon‐line shifts and magnetometry via optically detected magnetic resonances, enable simultaneous local thermometry and magnetic‐field measurements.
James Liddle‐Wesolowski, Konosuke Shimazaki, Jiyun Kim, Benjamin Whitefield, Kenji Watanabe, Takashi Taniguchi, Mehran Kianinia, Igor Aharonovich   +7 more
wiley   +1 more source

Mechanically Reprogrammed Coaxial Fibers for Multiphysics Transduction and Human‐Machine Interfaces

Advanced Science, EarlyView.
A continuously wet‐spun coaxial fiber is developed to combine stretchable conductivity, resistive sensing, and self‐powered triboelectric sensing in a single architecture. A mechanically reprogrammed dual‐network sheath stabilizes large deformation and improves signal reliability. These fibers can be woven into textile interfaces for multichannel touch
Xinyi Cao, Chao Ye, Shengjie Ling, Ming Li, Zhao Sha, Chun‐Hui Wang, Shuhua Peng   +6 more
wiley   +1 more source

Narratives and Contextualisation Gaps: A Preliminary Exploration of East Asian History Teaching

Scholaria: Jurnal Pendidikan dan Kebudayaan
East Asia exerts a significance influence on Southeast Asia, particularly Indonesia. Despites the existence of dedicated study center, a master’s program and even a compulsory course, research on the teaching of East Asian history in Indonesia high ...
Galuh Ambar Sasi
doaj   +1 more source

Sequential Regulation of Neurovascular Bone Regeneration in Large Bone Defects Using Black Phosphorus‐Europium Nanosheet Integrated TPMS Biomimetic Scaffold with Photo‐Controlled Ion Release

Advanced Science, EarlyView.
TPBE scaffolds, in conjunction with mild photothermal effects, effectively activate the PI3K/Akt signaling cascade, thereby promoting early neuronal differentiation and neurite growth. Short‐term (12 W) in vivo implantation studies revealed no significant pathological damage to major organs, providing preliminary evidence of the material's excellent ...
Bingqian Wang, Yuping Zhang, Xiaoning Su, Ning Liu, Hui Zeng, Bo Yang, Yang Xue, Fang Guo, Changkui Liu   +8 more
wiley   +1 more source