Results 101 to 110 of about 4,427 (164)
ChemistrySelect, Volume 10, Issue 17, May 5, 2025.A new set of spirooxindole‐ and spiroindenoquinoxaline‐derived pyrrolo[3,4‐c] pyrroles has been synthesized through atom‐economic one‐pot multicomponent reactions. Based on the results, compounds 4b and 5a demonstrated promising Glide scores and exhibited strong binding affinity with decaprenylphosphoryl‐β‐D‐ribofuranose oxidoreductase.
Mathiyazhagan Lavanya +8 more
wiley +1 more source
ChemistrySelect, Volume 10, Issue 17, May 5, 2025.This study synthesizes novel pyrimidine–pyrazole hybrids and evaluates their antimicrobial activity against bacterial pathogens by targeting penicillin‐binding protein 3 (PBP3). Several compounds show significant activity against E. faecium. Docking studies reveal strong binding with HMG‐CoA synthase, while in silico pharmacokinetic predictions ...
Suresh Choppadandi +4 more
wiley +1 more source
Nuclear Motion Is Classical: Spectrum of a Magic Protonated Water Cluster. [PDF]
Molecules, 2023 Frank I.
europepmc +1 more source
Structure of the Saccharolobus solfataricus GINS tetramer
Acta Crystallographica Section F, Volume 81, Issue 5, Page 207-215, May 2025.Archaeal organisms possess Cdc45 and GINS homologs that are likely to serve similar functional roles, but their structural interactions with the MCM helicase and hence their mechanism of MCM activation are not as well understood as for their eukaryotic counterparts. We present the crystal structure of the S.
Srihari Shankar, Eric J. Enemark
wiley +1 more source
Calibration to a Reference Determines when Schrödinger's Cats Die [PDF]
, 2023 Ken Krechmer
openalex +1 more source
Novel CTSA Variant Identified in a Thai Family With Late‐Infantile Galactosialidosis
Annals of Human Genetics, Volume 89, Issue 2-3, Page 126-131, May 2025.ABSTRACT Galactosialidosis (GS) is a rare lysosomal storage disease (LSD) with variable onset caused by a defect in protective protein/cathepsin A (PPCA) encoded by the CTSA gene. The late‐infantile onset is characterized by developmental delay, visceromegaly, coarse facies, and cherry‐red macula.
Lukana Ngiwsara +6 more
wiley +1 more source