Results 101 to 110 of about 6,522,895 (210)
Advanced Science, Volume 13, Issue 2, 9 January 2026.Arsenic in realgar induces CNS toxicity through direct and indirect effects: it activates ZBTB7A in astrocytes, which in turn inhibits glycolysis and impairs mice's learning, memory, and exploration; it also suppresses OTC in the liver to block the ornithine cycle, leading to blood ornithine accumulation that crosses into the frontal lobe and further ...
Ping Ye +7 more
wiley +1 more source
Molecular Insights into Fungal Glycosylphosphatidylinositol Transamidase Complex
Advanced Science, Volume 13, Issue 2, 9 January 2026.The glycosylphosphatidylinositol (GPI) biosynthesis pathway is critical for antifungal drug development. This study reports three cryo‐electron microscopy structures of fungal GPI transamidase (GPIT), captured in two substrate‐bound states and a novel dimeric assembly.
Zhengkang Hua +12 more
wiley +1 more source
Advanced Science, Volume 13, Issue 4, 19 January 2026.Puerarin targets mitochondrial MIC19 in tumor‐infiltrating Tregs, impairing their immunosuppressive function and enhancing antitumor immunity. This study uncovers the metabolic dependency of tumor‐infiltrating Tregs and highlights a potential metabolic‐targeted immunotherapeutic strategy for liver cancer. Abstract Regulatory T cells (Tregs) are pivotal
Yu Li +10 more
wiley +1 more source
Evidence of entanglement, or: Is Schrödinger's cat really entangled? [PDF]
, 2013 Kedar S. Ranade, K. Dechoum
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Advanced Science, Volume 13, Issue 1, 5 January 2026.Esophageal squamous cell carcinoma urgently requires new therapeutic strategies. Adenosine diphosphate‐ribosylation factor‐like protein 5B (ARL5B) is identified as a novel oncogene that remodels fatty acid metabolism through the ras homologous‐associated coiled‐coil containing protein kinase 1 (ROCK1)–sterol regulatory element‐binding protein 1 (SREBP1)
Xinyue Ma +12 more
wiley +1 more source
Dual Disruption of the Immune Cytokine Spätzle Facilitates Fungal Infection of Diverse Insect Hosts
Advanced Science, Volume 13, Issue 1, 5 January 2026.The Toll pathway is essential for insect defense against fungal pathogens. This works reports that fungal parasites employ two divergent virulent effectors to target the Toll receptor ligand Spätzle: a metalloprotease degrading it and a hairpin‐like effector hijacking it to block signal transduction. This dual strategy enables the fungus to kill a wide
Shuangxiu Song +7 more
wiley +1 more source
TDP43 aggregates: the ‘Schrödinger’s cat’ in amyotrophic lateral sclerosis
Nature Reviews Neuroscience, 2021 D. Lanznaster +4 more
semanticscholar +1 more source
Advanced Science, Volume 13, Issue 4, 19 January 2026.This study identifies the circadian transcription factor CLOCK (CLK) as a key regulator of oxidative stress resistance in fruit flies. CLK controls immune responses by driving rhythmic transcription of an RNA‐binding protein‐Achilles (ACHL) in the fly brain, which post‐transcriptionally represses the NF‐κB homolog Relish, limiting immune activation and
Xu Liu +7 more
wiley +1 more source
Bell's Conspiracy, Schrödinger's Black Cat and Global Invariant Sets [PDF]
, 2015 T. N. Palmer
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