Results 111 to 120 of about 6,522,895 (210)
Our research reveals that small‐molecule icariin (ICA) directly binds Ras‐GTPase‐activating protein SH3 domain‐binding protein 1 (G3BP1), inducing conformational change and oligomerization. This interaction confers neuroprotection by recruiting insulin‐like growth factor 2 mRNA‐binding protein 1 (IGF2BP1) and modulating N6‐methyladenosine (m6A ...
Ling Li +17 more
wiley +1 more source
Quantum Jumps in Amplitude Bistability: Tracking a Coherent and Invertible State Localization
A notable asymmetry is shown to characterize the bistable switching between macroscopic metastable states of light in the strong‐coupling limit of radiation–matter interaction. Transitions from the vacuum to a highly excited state correlate with a highly bunched sequence of emitted photons, while a downward switch to the vacuum involves a coherent ...
Th. K. Mavrogordatos
wiley +1 more source
Novel nitro‐substituted diaryl 1,3,4‐ and 1,2,4‐oxadiazoles were synthesised via molecular hybridisation of bioactive heterocycles. Selected derivatives exhibited potent antimicrobial activity, including against Mycobacterium tuberculosis and Staphylococcus aureus, and cholinesterase inhibitory activity, with promising selectivity.
Enikő Šikorová +9 more
wiley +1 more source
Virtual screening and activity evaluation of human uric acid transporter 1 (hURAT1) inhibitors. [PDF]
Yang Y +6 more
europepmc +1 more source
Schrödinger's Cheshire Cat: A tabletop experiment to measure the Diósi-Penrose collapse time and demonstrate Objective Reduction (OR) [PDF]
James Tagg, W. S. Reid, D. B. Carlin
openalex +1 more source
ABSTRACT Compound (E)‐1‐(((4‐chloro‐2‐hydroxyphenyl)imino)methyl)naphthalen‐2‐ol (HNC) was prepared by the reaction between 2‐hydroxynaphthyl‐1‐carboxaldehyde and 2‐amino‐5‐chlorophenol in an equimolar ratio and obtained in moderate yield. HNC was characterized using physicochemical and various spectroscopic techniques.
Segun D. Oladipo +5 more
wiley +1 more source
Schrödinger's cat and the clock: lessons for quantum gravity [PDF]
Robert Oeckl
openalex +1 more source
A set of three cysteine‐derived hydroxamic acids were synthesized and evaluated for human gloxalase‐1 inhibition and ferroptosis induction activities. Among them, compound 2 exhibited a potent inhibitory effect against human glyoxalase‐1 and induced ferroptosis in non‐small cell lung cancer cell lines, increasing reactive oxygen species production and ...
Josué Martínez‐Miranda +7 more
wiley +1 more source
Schrödinger's Cat: The Mysteries of Mental Health Nursing [PDF]
Anthony O’Brien
openalex +1 more source
Searching for Novel Antiviral Agents as COVID19 Treatments: Guanidino Diaryl Thioureas
Structure of the "hit‐compound" found and the proposed interaction with the active site of the TMPRSS2 protease, involving a reversible mechanism of action, are shown. The COVID‐19 pandemic highlighted the urgent need for effective antiviral treatments targeting SARS‐CoV‐2.
Marco Minneci +6 more
wiley +1 more source

