Results 111 to 120 of about 6,522,895 (210)

Targeting G3BP1 Condensate Topology Promotes Stress Granule Assembly via m6A‐IGF2BP1 for Ischemic Stroke Rescue

open access: yesAdvanced Science, Volume 13, Issue 6, 30 January 2026.
Our research reveals that small‐molecule icariin (ICA) directly binds Ras‐GTPase‐activating protein SH3 domain‐binding protein 1 (G3BP1), inducing conformational change and oligomerization. This interaction confers neuroprotection by recruiting insulin‐like growth factor 2 mRNA‐binding protein 1 (IGF2BP1) and modulating N6‐methyladenosine (m6A ...
Ling Li   +17 more
wiley   +1 more source

Quantum Jumps in Amplitude Bistability: Tracking a Coherent and Invertible State Localization

open access: yesAnnalen der Physik, Volume 538, Issue 1, January 2026.
A notable asymmetry is shown to characterize the bistable switching between macroscopic metastable states of light in the strong‐coupling limit of radiation–matter interaction. Transitions from the vacuum to a highly excited state correlate with a highly bunched sequence of emitted photons, while a downward switch to the vacuum involves a coherent ...
Th. K. Mavrogordatos
wiley   +1 more source

Activity Profiling of Nitro‐Substituted Di(Hetero)Aryl 1,3,4‐ and 1,2,4‐Oxadiazoles: Antimicrobial, Cholinesterase Inhibition and Antioxidant Potential

open access: yesArchiv der Pharmazie, Volume 359, Issue 1, January 2026.
Novel nitro‐substituted diaryl 1,3,4‐ and 1,2,4‐oxadiazoles were synthesised via molecular hybridisation of bioactive heterocycles. Selected derivatives exhibited potent antimicrobial activity, including against Mycobacterium tuberculosis and Staphylococcus aureus, and cholinesterase inhibitory activity, with promising selectivity.
Enikő Šikorová   +9 more
wiley   +1 more source

Schiff Base Compound of (E)‐1‐(((4‐chloro‐2‐hydroxyphenyl)imino)methyl)naphthalen‐2‐ol as CDK2 Inhibitory Agent: Structural Characterization, Density Functional Theory Computational, and In Silico studies

open access: yesChemistry &Biodiversity, Volume 23, Issue 1, January 2026.
ABSTRACT Compound (E)‐1‐(((4‐chloro‐2‐hydroxyphenyl)imino)methyl)naphthalen‐2‐ol (HNC) was prepared by the reaction between 2‐hydroxynaphthyl‐1‐carboxaldehyde and 2‐amino‐5‐chlorophenol in an equimolar ratio and obtained in moderate yield. HNC was characterized using physicochemical and various spectroscopic techniques.
Segun D. Oladipo   +5 more
wiley   +1 more source

Glyoxalase‐1 Inhibition Leads to Ferroptosis Induction in Lung Cancer Cells: A Dual Mechanism of Action of Hydroxamic Acids Derived from Cysteine

open access: yesChemMedChem, Volume 21, Issue 1, January 2026.
A set of three cysteine‐derived hydroxamic acids were synthesized and evaluated for human gloxalase‐1 inhibition and ferroptosis induction activities. Among them, compound 2 exhibited a potent inhibitory effect against human glyoxalase‐1 and induced ferroptosis in non‐small cell lung cancer cell lines, increasing reactive oxygen species production and ...
Josué Martínez‐Miranda   +7 more
wiley   +1 more source

Searching for Novel Antiviral Agents as COVID19 Treatments: Guanidino Diaryl Thioureas

open access: yesChemMedChem, Volume 21, Issue 1, January 2026.
Structure of the "hit‐compound" found and the proposed interaction with the active site of the TMPRSS2 protease, involving a reversible mechanism of action, are shown. The COVID‐19 pandemic highlighted the urgent need for effective antiviral treatments targeting SARS‐CoV‐2.
Marco Minneci   +6 more
wiley   +1 more source

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