Results 11 to 20 of about 4,427 (164)
BC‐11 is a covalent TMPRSS2 fragment inhibitor that impedes SARS‐CoV‐2 host cell entry
Archiv der Pharmazie, Volume 356, Issue 1, January 2023., 2023 Drug repurposing has the potential to accelerate the discovery of TMPRSS2 inhibitors acting as COVID‐19 antivirals. In this regard, a low throughput screening led to the identification of BC‐11 as a covalent TMPRSS2 fragment inhibitor (IC50 = 1.44 µM), displaying significant SARS‐CoV‐2 entry inhibition (EC50 = 66 µM). Abstract Host cell entry of severe
Aurélien F. A. Moumbock +3 more
wiley +1 more source
Archiv der Pharmazie, Volume 356, Issue 1, January 2023., 2023 Based on a simplified version of the morphinan scaffold, 3‐[3‐(phenalkylamino)cyclohexyl]phenol analogues were designed, synthesized and evaluated for their µ‐opioid receptor (MOR) antagonist activity in vitro and in silico. Docking studies indicate a peculiar combination of C‐1 stereochemistry and N‐substitutions as feasibly essential for MOR‐ligand ...
Graziella Tocco +8 more
wiley +1 more source
Schrödinger's Cat: Where Does The Entanglement Come From?
Quanta, 2017 Schrödinger's cat is one of the most striking paradoxes of quantum mechanics that reveals the counterintuitive aspects of the microscopic world. Here, I discuss the paradox in the framework of quantum information.
Radu Ionicioiu
doaj +1 more source
ChemMedChem, Volume 17, Issue 23, December 5, 2022., 2022 A new target: Bacterial sialic acid uptake inhibition is a promising strategy for the development of antibacterial drugs. In this study, we present the design, synthesis and evaluation of sialic acid 4‐piperidine and piperazine derivatives a novel compound class, which bind the SiaT from Proteus mirabilis and target a different portion of the binding ...
Tiago Bozzola +3 more
wiley +1 more source
Quantifying quantum coherence of optical cat states [PDF]
Photonics Research 9, 887 (2021), 2021 Optical cat state plays an essential role in quantum computation and quantum metrology. Here, we experimentally quantify quantum coherence of an optical cat state by means of relative entropy and l_1 norm of coherence in Fock basis based on the prepared optical cat state at rubidium D1 line. By transmitting the optical cat state through a lossy channel,
arxiv +1 more source
Cohomological estimates for $\cat(X,ξ)$ [PDF]
Geom. Topol. 11 (2007) 1255-1288, 2006 This paper studies the homotopy invariant $\cat(X,\xi)$ introduced in \cite{farbe2}. Given a finite cell-complex $X$, we study the function $\xi\mapsto \cat(X,\xi)$ where $\xi$ varies in the cohomology space $H^1(X;\R)$. Note that $\cat(X,\xi)$ turns into the classical Lusternik - Schnirelmann category $\cat(X)$ in the case $\xi=0$. Interest in $\cat(X,
arxiv +1 more source
CAT(0) spaces with polynomial divergence of geodesics [PDF]
Geometriae Dedicata, Online First, July 2012, 2011 We construct a family of finite 2-complexes whose universal covers are CAT(0) and have polynomial divergence of desired degree. This answers a question of Gersten, namely whether such CAT(0) complexes exist.
arxiv +1 more source
Groups acting on CAT(0) cube complexes [PDF]
Geom. Topol. 1 (1997) 1-7, 1997 We show that groups satisfying Kazhdan's property (T) have no unbounded actions on finite dimensional CAT(0) cube complexes, and deduce that there is a locally CAT(-1) Riemannian manifold which is not homotopy equivalent to any finite dimensional, locally CAT(0) cube complex.
arxiv +1 more source
Computational Modeling of Reticular Materials: The Past, the Present, and the Future
Advanced Materials, EarlyView.Reticular materials are advanced materials with applications in emerging technologies. A thorough understanding of material properties at operating conditions is critical to accelerate the deployment at an industrial scale. Herein, the status of computational modeling of reticular materials is reviewed, supplemented with topical examples highlighting ...
Wim Temmerman +3 more
wiley +1 more source
Understanding phenomena: From social to collective?
Philosophical Issues, Volume 32, Issue 1, Page 253-267, October 2022., 2022 Abstract In making sense of the world, we typically cooperate, join forces, and draw on one another's competence and expertise. A group or community in which there is a well‐functioning division of cognitive‐epistemic labor can achieve levels of understanding that a single agent who relies exclusively on her own capacities would probably never achieve.
Federica I. Malfatti
wiley +1 more source