Results 41 to 50 of about 4,427 (164)

Antioxidants and Antidiabetic Potential of Polyphenolic Fractions and Crude Extracts of Rhus coriaria L. Fruit, Punica granatum L. Peel, and Terminalia catappa L. Leaves: In Vitro and In Vivo Evaluation

Chemistry &Biodiversity, EarlyView.
This graphical abstract represents the extraction, characterization, and biological evaluation of bioactive compounds derived from specific plant sources. The top section illustrates Rhus coriaria (sumac) fruit, Punica granatum (pomegranate) peel and Terminalia catappa (Indian almond) leaves', which are known for their rich phytochemical composition ...
Mudassir Nazir, Muhammad Abdul Haq, Syed Arsalan Ali, Syed Muhammad Ghufran Saeed, Muhammad Ali Ajmal, Muhammad Nisar, Taseer Ahmed Khan, Alexandros Tsoupras, Shahina Naz   +8 more
wiley   +1 more source

Engineering and Structural Elucidation of a Sac7d‐Derived IgG Fc‐Specific Affitin and Its Application for the Light‐Controlled Affinity Purification of Antibodies

ChemBioChem, EarlyView.
An affitin derived from the Sac7d scaffold enables the light‐controlled affinity purification of antibodies under physiological conditions, thus overcoming limitations of protein A chromatography. X‐ray crystallographic analysis and affinity measurements reveal complex formation with Fc at the CH2/CH3 junction, similar to protein A/G and FnRn. Combined
Felix Veitl, Andreas Eichinger, Peter Mayrhofer, Markus R. Anneser, Mauricio Testanera, Kilian Rauscher, Matthias Lenz, Arne Skerra   +7 more
wiley   +1 more source

SAAP‐148 Oligomerizes into a Hexamer Forming a Hydrophobic Inner Core

ChemBioChem, EarlyView.
The highly cationic and hydrophobic antimicrobial peptide SAP‐148 effectively eradicates multidrug‐resistant bacteria, persistent cells, and biofilms without inducing resistance. Its efficiency is likely due to its ability to disrupt bacterial membranes as an oligomer, forming a stable alpha‐helical hexameric bundle with three parallel dimers that ...
Aden Hodzic, Djenana Vejzovic, Altea Topciu, Kirill Kuhlmann, Raj Kumar, Maria Andrea Mroginski, Alejandra de Miguel, Pia Hofmann, Klaus Zangger, Markus Weingarth, Robert A. Cordfunke, Jan W. Drijfhout, Peter Nibbering, Michal Belicka, Karl Lohner, Nermina Malanovic   +15 more
wiley   +1 more source

AI Cat Narrator: Designing an AI Tool for Exploring the Shared World and Social Connection with a Cat [PDF]

As technology continues to advance, the interaction between humans and cats is becoming more diverse. Our research introduces a new tool called the AI Cat Narrator, which offers a unique perspective on the shared lives of humans and cats. We combined the method of ethnography with fictional storytelling, using a defamiliarization strategy to merge real-
arxiv   +1 more source

Identification of key active site positions controlling the chemoselectivity of Aspergillus brasiliensis unspecific peroxygenase

ChemBioChem, Accepted Article.
Heme‐containing unspecific peroxygenases (UPOs) have catched significant attention as biocatalysts for oxidation reactions due to their ability to function without expensive nicotinamide cofactors. In our recent study, the UPO from Aspergillus brasiliensis (AbrUPO) was found to catalyze the aromatic hydroxylation of substituted benzenes, a feature that
Fabian Schmitz, Maike Hoffrogge, Katja Koschorreck, Yasuhisa Fukuta, Alessandra Raffaele, Florian Tieves, Thomas Hilberath, Frank Hollmann, Vlada B. Urlacher   +8 more
wiley   +1 more source

Design and Evaluation of Bivalent K‐Ras Inhibitors That Target the CAAX Binding Site and the Acidic Surface of Farnesyltransferase and Geranylgeranyltransferase I

Chemistry – A European Journal, EarlyView.
Chemical inhibition of K‐Ras posttranslational prenylation represents a promising strategy against aggressive cancers. A structure‐based design produces piperidine‐based peptidomimetics conjugated to cationic modules, effectively inhibiting FTase and GGTase I at single‐digit nanomolar concentrations.
Naomi Horiuchi, Rania Omer, Fumitoshi Sugino, Naomi Ogino, Yoshihisa Inoue, Kazi Aslamuzzaman, Takeyuki Suzuki, Said M. Sebti, Junko Ohkanda   +8 more
wiley   +1 more source

The Cat nRules [PDF]

arXiv, 2004
The nRules that are developed in another paper are applied to two versions of the Schrodinger cat experiment. In version I the initially conscious cat is made unconscious by a mechanism that is initiated by a radioactive decay. In version II the initially unconscious cat is awakened by a mechanism that is initiated by a radioactive decay. In both cases
arxiv  

Endohedral Coordination of Bulky Substrates in Metalloenzyme‐like Organometallic Nanotubes

Chemistry – A European Journal, Accepted Article.
Artificial receptors inspired by metalloenzymes share three key properties: a structurally flexible cavity, substrate binding via metal–ligand coordination, and metal‐based redox activity. Herein, we report an organometallic nanotube with such features based on our supramolecular pillarplex platform, with eight CuI centers integrated in its cavitand ...
Thomas Pickl, Patrick Mollik, Markus R. Anneser, Florian Sixt, Korbinian Geißer, Oksana Storcheva, Dominik P. Halter, Alexander Pöthig   +7 more
wiley   +1 more source

Asymptotically CAT(0) Groups [PDF]

arXiv, 2008
We study the general theory of asymptotically CAT(0) groups, explaining why such a group has finitely many conjugacy classes of finite subgroups, is $F_\infty$ and has solvable word problem. We provide techniques to combine asymptotically CAT(0) groups via direct products, amalgams and HNN extensions.
arxiv  

Small‐Molecule KRAS Inhibitors by Tyrosine Covalent Bond Formation

ChemMedChem, Accepted Article.
The development of the KRAS G12C inhibitor sotorasib was a major advance towards drugging KRAS. However, the G12C mutation is only found in about 10% of tumors with a KRAS mutation. KRAS tyrosine amino acids could provide alternative sites for covalent drug development.
Alexander Landgraf, Robert Brenner, Mona Ghozayel, Khuchtumur Bum-Erdene, Giovanni Gonzalez-Gutierrez, Samy Meroueh   +5 more
wiley   +1 more source