Results 91 to 100 of about 91,891 (247)

A Synergistic Inhibitor Development Strategy Against Human UDP‐Galactose‐4‐Epimerase

Angewandte Chemie International Edition, EarlyView.
The epimerase GalE is crucial for the biosynthesis of cancer‐relevant O‐GalNAc glycans. Here, we employ orthogonal, structurally enabled small molecule fragment screens to yield both covalent and non‐covalent inhibitors against GalE within no more than 22 elaborated compounds.
William M. Browne, Jonathan Pettinger, Teresa Weckwerth, Andrew Purkiss, Sing Hei Lok, Louisa Penicaut, Roksana Ogrodowicz, Raveena Prema, Simone Kunzelmann, Chloe Roustan, Ganka Bineva‐Todd, Saskia Pieters, Francesca Zappacosta, Alfred E. Doherty, Isobel Oram, Christelle Soudy, Robert Quinlan, Joanna Redmond, Svend Kjaer, David House, Stephane Mouilleron, Jacob T. Bush, Benjamin Schumann   +22 more
wiley   +1 more source

A Nonlinear Schrödinger Equation Resonating at an Essential Spectrum

Advances in Mathematical Physics, 2016
We consider the nonlinear Schrödinger equation -Δu+f(u)=V(x)u  in  RN. The potential function V satisfies that the essential spectrum of the Schrödinger operator -Δ-V is [0,+∞) and this Schrödinger operator has infinitely many negative eigenvalues ...
Shaowei Chen, Haijun Zhou
doaj   +1 more source

Work Versus Force: Simultaneous Processes for Describing Interactions

Advanced Physics Research, EarlyView.
ABSTRACT Achieving a unified description of interactions remains an open challenge in theoretical physics, which currently describes four fundamental forces. This situation may be viewed differently when interactions are formulated in terms of processes (work as actio) rather than forces (force as actio), not only at the macroscopic level but also at ...
Grit Kalies, Duong D. Do, Cornelia Breitkopf   +2 more
wiley   +1 more source

A Hybrid Semi‐Inverse Variational and Machine Learning Approach for the Schrödinger Equation

Advanced Physics Research, EarlyView.
A hybrid semi‐inverse variational and machine‐learning framework is presented for solving the Schrödinger equation with complex quantum potentials. Physics‐based variational solutions generate high‐quality training data, enabling Random Forest and Neural Network models to deliver near‐perfect energy predictions.
Khalid Reggab, Houssam Eddine Hailouf, Kingsley Onyebuchi Obodo, Mireille Megnidio‐Tchoukouegno, Mohammed Benali Kanoun, Souraya Goumri‐Said   +5 more
wiley   +1 more source

Ursolic Acid Alleviates Orchitis via Modulating Ferroptosis in Peritubular Myoid Cells of Testis

Animal Research and One Health, EarlyView.
Ursolic acid modulates key ferroptosis‐related pathways in the peritubular myoid cells of the testis in forest musk deer. ABSTRACT Chronic stress adversely affects reproductive health, increasing susceptibility to pathologies such as orchitis. Additionally, the maintenance of iron homeostasis is essential for preserving the function of the testicles ...
Yang Wang, Tianqi Jin, Zexin Chen, Ye Gong, Qimin Liu, Zifang Wu, Heran Cao, Yan Li, Yuyan Liu, Tianhao Yang, Zhihong Jiang, Wuzi Dong   +11 more
wiley   +1 more source

Affinity Peptides With pH Sensitivity for the Enrichment of CD38+ Cells

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The selective enrichment of cell populations based on surface markers is critical for the advancement of gene and cell therapies. Current antibody‐based cell isolation methods, such as fluorescence‐ and magnetic‐activated cell sorting (FACS and MACS), offer high specificity but are limited by scalability, cost, and potential adverse effects on
Gabrielle Rusch, Mickael Meyer, I. Mohamed Irfan, Carson Huber, Joseph Burclaff, Scott T. Magness, Stefano Menegatti, Michael Daniele   +7 more
wiley   +1 more source

Optimization of CEST MRI Reporter Protein Design Using Cation‐Pi Networks

Chemistry – A European Journal, EarlyView.
A novel engineering approach can produce reporter proteins for cell and viral therapy tracking with unique magnetic resonance imaging (MRI) signatures, detectable with chemical exchange saturation transfer (CEST). We discover how cation‐π interactions between amino acid groups can help us fine‐tune magnetic resonance properties for noninvasive ...
David E. Korenchan, Ethan J. French, Emerenziana Runco, Chetan B. Dhakan, Jinwu Yan, Hiroshi Nakashima, Michael T. McMahon, Assaf A. Gilad, Christian T. Farrar   +8 more
wiley   +1 more source

Post‐LECA Origin and Diversification of an Axonemal Outer Arm Dynein Motor

Cytoskeleton, EarlyView.
ABSTRACT Dyneins were present in the last eukaryotic common ancestor (LECA) and play key roles in eukaryotic biology. Axonemal dyneins form the inner and outer arms that power ciliary beating, and it has long been recognized that outer arms in some organisms contain two different heavy chain motors, whereas those from other species contain a third unit
Stephen M. King
wiley   +1 more source

Existence, regularity and positivity of ground states for nonlocal nonlinear Schrodinger equations

Electronic Journal of Differential Equations, 2019
We study ground states of a nonlinear Schr\"odinger equation driven by the infinitesimal generator of a rotationally invariant Levy process. The equation includes many special cases such as classical Schrodinger equations, fractional Schrodinger ...
Yong-Chao Zhang
doaj  

Self‐Similar Blowup for the Cubic Schrödinger Equation

Communications on Pure and Applied Mathematics, EarlyView.
ABSTRACT We give a rigorous proof for the existence of a finite‐energy, self‐similar solution to the focusing cubic Schrödinger equation in three spatial dimensions. The proof is computer‐assisted and relies on a fixed point argument that shows the existence of a solution in the vicinity of a numerically constructed approximation.
Roland Donninger, Birgit Schörkhuber
wiley   +1 more source