Results 261 to 270 of about 3,339,817 (343)

A signal transduction blind spot: the function of adenylyl cyclase transmembrane domains

The FEBS Journal, EarlyView.
Transmembrane adenylyl cyclases (tmACs) are essential for synthesising the universal second messenger cyclic AMP. All tmACs share a common topology that includes a large 12‐helix transmembrane (TM) domain. This domain accounts for ~ 35% of the coding sequence but its function is still an open question.
Ryan S. Dowsell, Matthew G. Gold
wiley   +1 more source

A new variable-step method for the numerical integration of special second-order initial value problems and their application to the one-dimensional Schrödinger equation

, 1993
T. E. Simos
openalex   +1 more source

The deubiquitinase inhibitor WP1130 drives nuclear aggregation and reactivation of mutant p53 for selective cancer cell targeting

The FEBS Journal, EarlyView.
Targeting the stability of oncogenic mutant p53 (mutp53) presents a promising strategy for cancer therapy. This study identifies the deubiquitinases (DUBs) USP5 and USP9X as key regulators of mutp53 stability. The DUB inhibitor WP1130 selectively destabilized mutp53 by promoting its ubiquitination, nuclear aggregation, and degradation via the ...
Swapnil Oak, Onkar Karajgikar, Nikhil Gadewal, Prasad Sulkshane, Tripti Verma, Sanjay Gupta, Tanuja Teni   +6 more
wiley   +1 more source

Asymptotic behaviour for a weakly damped schrödinger equation in dimension two

, 1993
Mostafa Abounouh
openalex   +1 more source

Stabilization of the catalytically active structure of a molybdenum‐dependent formate dehydrogenase depends on a highly conserved lysine residue

The FEBS Journal, EarlyView.
Molybdenum‐dependent formate dehydrogenases (Mo‐FDHs) contain a strictly conserved lysine residue (K44) in the vicinity of an electron‐transferring [4Fe‐4S] cluster and a catalytically active molybdenum atom coordinated by two molybdopterins (MPT‐1 and MPT‐2).
Feilong Li, Michael Lienemann
wiley   +1 more source

Pharmacological manipulation of liver fibrosis progression using novel HDAC6 inhibitors

The FEBS Journal, EarlyView.
Chronic liver injury can lead to severe conditions such as cirrhosis and liver cancer. Unfortunately, there are no effective treatments to halt or reverse liver fibrosis, which makes new therapeutic strategies essential. This study focuses on the role of histone deacetylases (HDACs) in liver fibrosis, particularly HDAC6.
Maria Teresa Borrello, Dusan Ruzic, Hannah Paish, Eleanor Graham, Amy L. Collins, Rebecca Scott, Sam Higginbotham, Branko Radovic, Glyn Nelson, David Bulmer, Lee A. Borthwick, Stuart M. Robinson, Jeremy French, John Moir, Steve A. White, Colin Wilson, Sanjay Pandanaboyana, John Hammond, Rohan Thakkar, Wasfi Alrawashdeh, Rodrigo Figueiredo, Milos Petkovic, Katarina Nikolic, Fiona Oakley, Derek A. Mann, Jelena Mann   +25 more
wiley   +1 more source

Propagation of wave insights to the Chiral Schrödinger equation along with bifurcation analysis and diverse optical soliton solutions.

Sci Rep
Alkahtani BST.
europepmc   +1 more source

Space-time behavior of propagators for Schrödinger evolution equations with Stark effect

, 1991
Tohru Ozawa
openalex   +1 more source

First‐in‐class inhibitors of SbnA reduce siderophore production in Staphylococcus aureus

The FEBS Journal, EarlyView.
The production of the iron‐chelating compound staphyloferrin B by the most invasive S. aureus strains is crucial for colonization, virulence, and survival in the host. Staphyloferrin B biosynthesis is carried out by eight enzymes, the Sbn system, that offer an appealing source of potential targets for the development of antimicrobials.
Sarah Hijazi, Monica Cozzi, Somayeh Asgharpour, Omar De Bei, Serena Faggiano, Francesco Marchesani, Luca Ronda, Marialaura Marchetti, Eleonora Gianquinto, Mariacristina Failla, Gauthier Trèves, Loretta Lazzarato, Francesca Spyrakis, Barbara Campanini, Emanuela Frangipani, Stefano Bettati   +15 more
wiley   +1 more source

Far‐right movement parties in Europe: Two perspectives

Nations and Nationalism, EarlyView.
Abstract Taking as a starting point the growing body of scholarship on movement parties of the far right, this research note undertakes a reflection on the boundaries of the movement party concept from two distinct angles – the established interactive‐mobilisational approach and the more recent discursive‐organisational one – and their empirical ...
Seongcheol Kim
wiley   +1 more source