Results 91 to 100 of about 179 (110)

High‐throughput screen identifies MAS9 as a novel inhibitor of the C‐type lectin receptor‐2 (CLEC‐2)–podoplanin interaction

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 16, Page 3838-3851, August 2025.
Abstract Background and Purpose The C‐type lectin‐like receptor‐2 (CLEC‐2) is a platelet receptor for the endogenous ligand podoplanin. This interaction contributes to several (patho)physiological processes, such as lymphangiogenesis, preservation of blood and lymphatic vessel integrity organ development, and tumour metastasis.
Marcin A. Sowa   +8 more
wiley   +1 more source

Repurposing of FDA‐Approved Drugs to Disrupt Iron Uptake in Mycobacterium abscessus: Targeting Salicylate Synthase as a Novel Approach

open access: yesChemical Biology &Drug Design, Volume 106, Issue 2, August 2025.
A drug repurposing strategy was applied against M. abscessus, through a virtual screening of FDA approved drugs on salicylate synthase. Eleven potential ligands were found; among these, three were confirmed as potent inhibitors of the enzyme. ABSTRACT Non‐tuberculous mycobacteria (NTM) are opportunistic pathogens that lead to severe, persistent ...
Giovanni Stelitano   +7 more
wiley   +1 more source

Quantum Powers and Primitive Ontology

open access: yesPhilosophy Compass, Volume 20, Issue 8, August 2025.
ABSTRACT This article surveys recent work on primitive ontology (PO) approaches to quantum mechanics, focusing on proposals that seek to integrate this approach with the metaphysics of causal powers. PO approaches aim to provide a clear metaphysical picture in which the world consists of local entities such as particles, matter density fields or ...
William M. R. Simpson
wiley   +1 more source

Schrödinger, Szilard, and the emergence of the EPR argument [PDF]

open access: yes
Einstein, Podolsky and Rosen’s “Can quantum mechanical description of reality be considered complete?”(1935) and Schrödinger’s “Die gegenwärtige Situation in der Quantenmechanik” (1936) are commonly accepted as the seminal papers for the modern study of ...
Lehner, Christoph Albert, Uffink, Jos
core  

Design of Potent Mannose‐6‐Phosphate Derivatives as Ligands for CI‐M6P/IGF2R Using Fluorescence Polarization Assay

open access: yesChemistry – A European Journal, Volume 31, Issue 41, July 22, 2025.
We designed and synthesized novel mannose‐6‐phosphate (M6P) derivatives to enhance their binding affinity for the CI‐M6P/IGF2 receptor, which plays a key role in lysosomal targeting. Using a fluorescence polarization assay, we evaluated di‐, tri‐, and penta‐M6P peptides and modified M6P analogs.
Lucie Mrázková   +11 more
wiley   +1 more source

Mammalian hydroxylation of microbiome-derived obesogen, delta-valerobetaine, to homocarnitine, a 5-carbon carnitine analog. [PDF]

open access: yesJ Biol Chem
Weinberg J   +13 more
europepmc   +1 more source

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