Results 101 to 110 of about 4,189 (126)

z.B. Zeitschrift zum Beispiel Nummer 1 [PDF]

open access: yes, 2018
Diese neue Zeitschrift soll dem Beispiel gewidmet sein – genauer: dem Beispielgebrauch. Wir benötigen und gebrauchen Beispiele. Das gilt – sobald wir etwas explizieren, veranschaulichen oder begründen wollen – für unseren alltäglichen Sprachgebrauch, für

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Computational Design, Synthesis, and Biological Assessment of Some Pyrrolo[3,4‐c]Pyrroles Targeting Mycobacterium Tuberculosis

open access: yesChemistrySelect, Volume 10, Issue 17, May 5, 2025.
A new set of spirooxindole‐ and spiroindenoquinoxaline‐derived pyrrolo[3,4‐c] pyrroles has been synthesized through atom‐economic one‐pot multicomponent reactions. Based on the results, compounds 4b and 5a demonstrated promising Glide scores and exhibited strong binding affinity with decaprenylphosphoryl‐β‐D‐ribofuranose oxidoreductase.
Mathiyazhagan Lavanya   +8 more
wiley   +1 more source

Lithium and brain plasticity - studies on glial cell changes and electroconvulsive treatment-induced amnesia in rats [PDF]

open access: yes, 2013
Depression and bipolar disorder, collectively known as mood disorders, are devastating, common and often chronic illnesses. Imaging studies of patients with mood disorders have demonstrated structural changes in several brain regions implicated in mood ...
Orre, Karin
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Design, Synthesis, and Antibacterial Evaluation of Pyrazole Pyrimidine Hybrids: Integrative In Vitro and In Silico Studies

open access: yesChemistrySelect, Volume 10, Issue 17, May 5, 2025.
This study synthesizes novel pyrimidine–pyrazole hybrids and evaluates their antimicrobial activity against bacterial pathogens by targeting penicillin‐binding protein 3 (PBP3). Several compounds show significant activity against E. faecium. Docking studies reveal strong binding with HMG‐CoA synthase, while in silico pharmacokinetic predictions ...
Suresh Choppadandi   +4 more
wiley   +1 more source

Structure of the Saccharolobus solfataricus GINS tetramer

open access: yesActa Crystallographica Section F, Volume 81, Issue 5, Page 207-215, May 2025.
Archaeal organisms possess Cdc45 and GINS homologs that are likely to serve similar functional roles, but their structural interactions with the MCM helicase and hence their mechanism of MCM activation are not as well understood as for their eukaryotic counterparts. We present the crystal structure of the S.
Srihari Shankar, Eric J. Enemark
wiley   +1 more source

Mathematics meets physics: A contribution to their interaction in the 19th and the first half of the 20th century [PDF]

open access: yes, 2017
Es gibt wohl kaum Wissenschaftsgebiete, in denen die wechselseitige Beeinflussung stärker ist als zwischen Mathematik und Physik. Eine wichtige Frage ist dabei die nach der konkreten Ausgestaltung dieser Wechselbeziehungen, etwa an einer Universität ...
Schlote, Karl-Heinz, Schneider, Martina
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Novel CTSA Variant Identified in a Thai Family With Late‐Infantile Galactosialidosis

open access: yesAnnals of Human Genetics, Volume 89, Issue 2-3, Page 126-131, May 2025.
ABSTRACT Galactosialidosis (GS) is a rare lysosomal storage disease (LSD) with variable onset caused by a defect in protective protein/cathepsin A (PPCA) encoded by the CTSA gene. The late‐infantile onset is characterized by developmental delay, visceromegaly, coarse facies, and cherry‐red macula.
Lukana Ngiwsara   +6 more
wiley   +1 more source

Computational and Experimental Druggability Assessment of Human DNA Glycosylases. [PDF]

open access: yesACS Omega, 2019
Michel M   +14 more
europepmc   +1 more source

Schrödinger, Szilard, and the emergence of the EPR argument [PDF]

open access: yes
Einstein, Podolsky and Rosen’s “Can quantum mechanical description of reality be considered complete?”(1935) and Schrödinger’s “Die gegenwärtige Situation in der Quantenmechanik” (1936) are commonly accepted as the seminal papers for the modern study of ...
Lehner, Christoph Albert, Uffink, Jos
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