Results 11 to 20 of about 4,189 (126)

BC‐11 is a covalent TMPRSS2 fragment inhibitor that impedes SARS‐CoV‐2 host cell entry

Archiv der Pharmazie, Volume 356, Issue 1, January 2023., 2023
Drug repurposing has the potential to accelerate the discovery of TMPRSS2 inhibitors acting as COVID‐19 antivirals. In this regard, a low throughput screening led to the identification of BC‐11 as a covalent TMPRSS2 fragment inhibitor (IC50 = 1.44 µM), displaying significant SARS‐CoV‐2 entry inhibition (EC50 = 66 µM). Abstract Host cell entry of severe
Aurélien F. A. Moumbock, Hoai T. T. Tran, Evelyn Lamy, Stefan Günther   +3 more
wiley   +1 more source

3‐[3‐(Phenalkylamino)cyclohexyl]phenols: Synthesis, biological activity, and in silico investigation of a naltrexone‐derived novel class of MOR‐antagonists

Archiv der Pharmazie, Volume 356, Issue 1, January 2023., 2023
Based on a simplified version of the morphinan scaffold, 3‐[3‐(phenalkylamino)cyclohexyl]phenol analogues were designed, synthesized and evaluated for their µ‐opioid receptor (MOR) antagonist activity in vitro and in silico. Docking studies indicate a peculiar combination of C‐1 stereochemistry and N‐substitutions as feasibly essential for MOR‐ligand ...
Graziella Tocco, Antonio Laus, Maksims Vanejevs, Anastasija Ture, Rafaela Mostallino, Nicholas Pintori, Maria Antonietta De Luca, M. Paola Castelli, Gaetano Di Chiara   +8 more
wiley   +1 more source

Sialic Acid 4‐N‐Piperazine and Piperidine Derivatives Bind with High Affinity to the P. mirabilis Sialic Acid Sodium Solute Symporter

ChemMedChem, Volume 17, Issue 23, December 5, 2022., 2022
A new target: Bacterial sialic acid uptake inhibition is a promising strategy for the development of antibacterial drugs. In this study, we present the design, synthesis and evaluation of sialic acid 4‐piperidine and piperazine derivatives a novel compound class, which bind the SiaT from Proteus mirabilis and target a different portion of the binding ...
Tiago Bozzola, Richard E. Johnsson, Ulf J. Nilsson, Ulf Ellervik   +3 more
wiley   +1 more source

QUANTUM META-THEORY (Twisting the Tail of Schrödinger’s Cat) [PDF]

, 2018
The problem of Schrödinger’s Cat has figured prominently in the debates about the bearing of quantum physics on our understanding of physical reality. On its basis, various theorists have maintained the quantum physical world exhibits a probabilistically
Rescher, Nicholas
core   +2 more sources

Magnetic qubits as hardware for quantum computers

, 2000
We propose two potential realisations for quantum bits based on nanometre scale magnetic particles of large spin S and high anisotropy molecular clusters. In case (1) the bit-value basis states |0> and |1> are the ground and first excited spin states Sz =
Barenco A, Bennett C H, Chudnovsky E M, del Barco E, DiVincenzo D P, DiVincenzo D P, DiVincenzo D P, E del Barco, E M Chudnovsky, Friedman J R, Gider S, Grover L K, Grover L K, Hernandez J M, J M Hernandez, J Tejada, Lloyd S, Lo H-K, Prokof'ev N V, Schwarzschild B, Shor P W, Shor P W, Shor P W, Shor P W, Shor P W, Shor P W, Stamp P C, T P Spiller, Thomas L   +28 more
core   +1 more source

The place of preservation of the false : mistakes, accidents and homonyms in the novel "Sand" by Wolfgang Herrndorf [PDF]

, 2013
This paper aims to examine Wolfgang Herrndorf's novel "Sand" (2011), taking into consideration its concatenation of errors, accidents and the logic of the absurd. The first part of this investigation regards the different connotations of the desert motif
Arnold, Sonja
core   +4 more sources

CAT(0) spaces with polynomial divergence of geodesics [PDF]

Geometriae Dedicata, Online First, July 2012, 2011
We construct a family of finite 2-complexes whose universal covers are CAT(0) and have polynomial divergence of desired degree. This answers a question of Gersten, namely whether such CAT(0) complexes exist.
arxiv   +1 more source

Researching Young People’s Sexualized Digital Practices Involving Imagery: : A Transmethodological Approach [PDF]

, 2021
Young people constitute and negotiate their gendered identities and belonging, as well as their romantic and erotic relationships, through sexualized digital practices involving imagery.
Rasmussen, Penille Kærsmose Bøegh
core   +1 more source

Ψυχοθεραπεία με ψηφιακή διαμεσολάβηση: Οικειότητα, απόσταση και σύνδεση σε εικονικούς θεραπευτικούς χώρους [PDF]

This paper is a commentary on the articles in this Technology, AI Bots and Psychology Special Issue. The Special Issue presents a range of conceptual, practice-based and empirical reflections on digitally mediated therapy. This includes looking back to a
Tucker, I., Tucker, I.
core   +1 more source

Groups acting on CAT(0) cube complexes [PDF]

Geom. Topol. 1 (1997) 1-7, 1997
We show that groups satisfying Kazhdan's property (T) have no unbounded actions on finite dimensional CAT(0) cube complexes, and deduce that there is a locally CAT(-1) Riemannian manifold which is not homotopy equivalent to any finite dimensional, locally CAT(0) cube complex.
arxiv   +1 more source