Results 61 to 70 of about 4,189 (126)

Agents and Responsibility Under the Many Worlds Interpretation of Quantum Mechanics [PDF]

open access: yes, 2013
Bachelors Honours Thesis: Much philosophical thought has been given to the subject of personal identity. However, almost all of the discourse on personal identity seems to assume the Copenhagen Interpretation of ...
Firth, Steven J.
core  

Design and Evaluation of Bivalent K‐Ras Inhibitors That Target the CAAX Binding Site and the Acidic Surface of Farnesyltransferase and Geranylgeranyltransferase I

open access: yesChemistry – A European Journal, EarlyView.
Chemical inhibition of K‐Ras posttranslational prenylation represents a promising strategy against aggressive cancers. A structure‐based design produces piperidine‐based peptidomimetics conjugated to cationic modules, effectively inhibiting FTase and GGTase I at single‐digit nanomolar concentrations.
Naomi Horiuchi   +8 more
wiley   +1 more source

The Cat nRules [PDF]

open access: yesarXiv, 2004
The nRules that are developed in another paper are applied to two versions of the Schrodinger cat experiment. In version I the initially conscious cat is made unconscious by a mechanism that is initiated by a radioactive decay. In version II the initially unconscious cat is awakened by a mechanism that is initiated by a radioactive decay. In both cases
arxiv  

Primary care and the COVID-19 pandemic: Schrödinger's cat

open access: yesERJ Open Research, 2021
Emmanouil K Symvoulakis   +1 more
doaj   +1 more source

Asymptotically CAT(0) Groups [PDF]

open access: yesarXiv, 2008
We study the general theory of asymptotically CAT(0) groups, explaining why such a group has finitely many conjugacy classes of finite subgroups, is $F_\infty$ and has solvable word problem. We provide techniques to combine asymptotically CAT(0) groups via direct products, amalgams and HNN extensions.
arxiv  

Small‐Molecule KRAS Inhibitors by Tyrosine Covalent Bond Formation

open access: yesChemMedChem, Accepted Article.
The development of the KRAS G12C inhibitor sotorasib was a major advance towards drugging KRAS. However, the G12C mutation is only found in about 10% of tumors with a KRAS mutation. KRAS tyrosine amino acids could provide alternative sites for covalent drug development.
Alexander Landgraf   +5 more
wiley   +1 more source

Isoniazid‐Dihydropyrimidinone Molecular Hybrids: Design, Synthesis, Antitubercular Activity, and Cytotoxicity Investigations with Computational Validation

open access: yesChemMedChem, EarlyView.
Antitubercular evaluation of a novel library of isoniazid‐dihydropyrimidinone molecular hybrids (8a–8n) discloses a potent compound with MIC = 0.39μg mL−1 against M. tuberculosis mc26230. Cytotoxicity, stability, and in silico studies, including molecular docking and ADME/T (absorption, distribution, metabolism, excretion, and toxicity) analysis ...
Gobind Kumar   +10 more
wiley   +1 more source

On non-locally connected boundaries of CAT(0) spaces [PDF]

open access: yesarXiv, 2006
In this paper, we study CAT(0) spaces with non-locally connected boundary. We give some condition of a CAT(0) space whose boundary is not locally connected.
arxiv  

Electrochemical Three‐component Synthesis of Alkenesulfonates from Cinnamic Acids, SO2, and Alcohols

open access: yesChemSusChem, EarlyView.
An electrochemical three‐component synthesis of alkyl alkenesulfonates from cinnamic acids, SO2, and alkyl alcohols is reported. This metal‐free process employs inexpensive and readily available graphite electrodes in combination with easy‐to‐use stock solutions of SO2 and enables a straightforward decarboxylative preparation of styrene sulfonates via ...
Po‐Chung Chien   +4 more
wiley   +1 more source

FROM SCHRÖDINGER’S CAT TOWARDS A QUANTUM APPROACH OF ACCOUNTING ESTIMATES, JUDGMENTS AND DECISION MAKING

open access: yesAnnals of the University of Oradea: Economic Science, 2016
Addressing regions competitiveness is relatively new in literature. The main cause of increasing interest for this concept is the development of the European Union put in a position to integrate, countries with different levels of development, formed themselves from regions heterogeneous in terms of economic efficiency.
openaire   +1 more source

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