Results 261 to 270 of about 25,004 (307)

Optimisation of a Novel Class of DNA Gyrase Inhibitors to Improve Antibacterial Activity

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
This article describes efforts to increase the antibacterial activity of a recently reported class of novel DNA gyrase inhibitors known as the isoquinoline sulphonamides by improving their uptake in bacterial cells. As antibiotic resistance continues to rise, the need for new antibacterials is clear.
Meg I. Ferguson, Cerissa C. van Walstijn, Vladyslav Lysenko, Marta A. Wilbrink, David Alencar Araripe, Jeroen M. Punt, Mario van der Stelt, Willem Jespers, Paolo Innocenti, Nathaniel I. Martin   +9 more
wiley   +1 more source

Interactions among lump optical solitons for coupled nonlinear Schrödinger equation with variable coefficient via bilinear method. [PDF]

Sci Rep
Wen S, Manafian J, Sedighi S, Atmaca SP, Gallegos C, Mahmoud KH, Alsubaie ASA.   +6 more
europepmc   +1 more source

Seniority‐Zero Quadratic Canonical Transformation Theory

International Journal of Quantum Chemistry, Volume 126, Issue 12, June 15, 2026.
We construct a unitary transformation of electronic Hamiltonians using quadratic canonical transformation theory, choosing the transformation to minimize the non‐seniority‐zero elements of the transformed Hamiltonian. This allows us to add dynamic correlation to the static correlation inherent in orbital‐optimized doubly‐occupied (seniority‐zero ...
Daniel F. Calero‐Osorio, Paul W. Ayers
wiley   +1 more source

Global well-posedness of the 2D nonlinear Schrödinger equation with multiplicative spatial white noise on the full space. [PDF]

Probab Theory Relat Fields
Debussche A, Liu R, Tzvetkov N, Visciglia N.   +3 more
europepmc   +1 more source

High‐Energy Topological Edge States and Strain‐Induced Multiple Flat Bands in a Honeycomb Lattice

Nanophotonics, Volume 15, Issue 11, 13 June 2026.
This work proposes a novel anti‐twig edge in the honeycomb lattice that supports two symmetric high‐energy edge states. Moreover, the suppression or enhancement of the high‐energy edge state is observed, and strain‐induced multiple flat bands are produced.
Xiaoqin Bai, Haozhen Tian, Boris A. Malomed, Rongcao Yang, Xiaojun Jia   +4 more
wiley   +1 more source

An efficient computational scheme for solving coupled time-fractional Schrödinger equation via cubic B-spline functions. [PDF]

PLoS One
Mubashir Hayat A, Abbas M, Emadifar H, Alzaidi ASM, Nazir T, Aini Abdullah F.   +5 more
europepmc   +1 more source

Enantioselective Synthesis of Lactic Acid From CO2 Using a Novel Pyruvate Decarboxylase in a Scalable Biocatalytic Cascade

Advanced Synthesis &Catalysis, Volume 368, Issue 11, 3 June 2026.
We report a scalable biocatalytic cascade that converts CO2 and acetaldehyde to pyruvate via a newly characterized pyruvate decarboxylase, followed by stereoselective reduction to lactic acid. The system enables fully switchable enantioselectivity using either L‐ or D‐lactate dehydrogenases.
Silvia Fruncillo, Daan M. van Vliet, Jurgen J. Mateman, Dirk C. van Seijst, Jan Stoutjesdijk, Jason van Rooyen, Akash Pandya, James Galman, Annette Alcasabas, Tom A. Ewing   +9 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, Volume 600, Issue 11, Page 1621-1637, June 2026.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Local Well-Posedness of the Periodic Nonlinear Schrödinger Equation with a Quadratic Nonlinearity u ¯ 2 in Negative Sobolev Spaces. [PDF]

J Dyn Differ Equ
Liu R.
europepmc   +1 more source

Propagation of wave insights to the Chiral Schrödinger equation along with bifurcation analysis and diverse optical soliton solutions.

Sci Rep
Alkahtani BST.
europepmc   +1 more source