Results 101 to 110 of about 19,665 (223)

A PK/PD study on antihyperalgesia by an α2/3‐GABAA receptor PAM in mice: Lack of tolerance liability and potential involvement of γ1‐GABAA receptors

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose GABAA receptors (GABAARs) are heteropentameric ion channels that control almost all CNS functions, including spinal nociception. Most GABAARs contain a γ2 subunit but differ in their α and β subunit composition. TPA023B is an α2/α3 subtype selective, non‐sedative, positive allosteric modulator (PAM) with antihyperalgesic
Elena Neumann, Mariana O. Popa, Karen T. Elvers, Misa Oyama, Daniel Ulrich, Marcus Hanley, Gui Jie Feng, Thomas Hathaway, William T. Ralvenius, Thomas Grampp, Dietmar Benke, John R. Atack, Hanns Ulrich Zeilhofer   +12 more
wiley   +1 more source

A new concept for evaluating muscle function in the lower extremities in cases of low back pain syndrome in anamnesis

Annals of Agricultural and Environmental Medicine, 2014
introduction. There are difficulties in objective evaluation of activity of the muscles in the lower extremities of patients after successful treatment of sciatica and pseudosciatica, when no clear clinical symptoms are detected.
Przemysław Lisiński , Juliusz Huber , Jagoda Ciesielska, Joanna Lipiec , Aleksandra Kulczyk , Agata Bandosz , Wioletta Żukiewicz-Sobczak, Ewa Mojs , Włodzimierz Samborski   +8 more
doaj  

LPC18:0 Secreted by Exogenous Neural Stem Cells Potentiates Neurogenesis and Functional Recovery via GPR55‐Mediated Signalling in Spinal Cord Injury

Cell Proliferation, EarlyView.
LPC18:0 secreted by exogenous neural stem cells potentiates neurogenesis via the GPR55/AKT/GSK3β signalling axis, which ultimately promotes spinal cord injury recovery. ABSTRACT Spinal cord injury (SCI) is a devastating condition with limited therapeutic options. Although neural stem cell (NSC) transplantation shows regenerative potential, its efficacy
Dong Chen, Shuo Liu, Le‐Yi Tu, Ming‐Mei Yang, Cong‐Wang Xu, Yue Jiang, Hui Yang, Chen‐Xu Tai, Yan‐Ning Wang, Yuan‐Yuan Xie, Ping‐Ping Shen, Bin Wang   +11 more
wiley   +1 more source

Therapeutic potential of mesenchymal stem cells in peripheral nerve injuries in horses

Equine Veterinary Education, EarlyView.
Summary Peripheral nerve injuries (PNI) in horses represent a significant clinical challenge, frequently associated with functional deficits and reduced athletic performance. Conventional therapeutic approaches, primarily based on anti‐inflammatory treatments and rehabilitation, offer limited efficacy, driving the search for innovative alternatives. In
L. V. de Oliveira Ferreira, R. Martins Amorim   +1 more
wiley   +1 more source

Developing a Core Outcome Set for Clinical Trials of Traditional Chinese Medicine for Lumbar Disc Herniation

Journal of Evidence-Based Medicine, EarlyView.
ABSTRACT Background Traditional Chinese medicine (TCM) is widely used in managing lumbar disc herniation (LDH), but heterogeneous outcome reporting in its trials hinders evidence synthesis. This study intends to develop a core outcome set (COS) for TCM‐LDH to standardize reporting and improve research quality. Methods Candidate outcomes were identified
Xiaokuan Qin, Kai Sun, Xiangyu Xiao, Junhua Zhang, Chengliang Wu, Bin Shi, Bo Pang, Liguo Zhu, Xu Wei   +8 more
wiley   +1 more source

Stem Cells From Dental Pulp, Periodontal Tissues, and Other Oral Sources: Biological Concepts and Regenerative Potential

Journal of Periodontal Research, EarlyView.
A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed, Sara El Moshy, Israa Ahmed Radwan, Dina Rady, Aiah A. El‐Rashidy, Marwa M. S. Abbass, Christof E. Dörfer   +6 more
wiley   +1 more source

Partial tarsal arthrodesis with plate fixation for management of traumatic tarsometatarsal injuries in five cats

Journal of Small Animal Practice, EarlyView.
Objectives To describe the aetiology, presentation, complications and outcome in cats with traumatic injuries of the tarsometatarsal joint treated with partial tarsal arthrodesis. Materials and Methods Retrospective series of five client‐owned cats. Medical records were retrieved for cats with traumatic injuries of the tarsometatarsal joint treated ...
R. L. Nixon, D. N. Clements, J. M. Ryan
wiley   +1 more source

Anatomical Study of Lateral Compression II Screw Path and Entry Parameters Based on Three‐Dimensional CT Image Reconstruction Techniques

Orthopaedic Surgery, Volume 17, Issue 5, Page 1454-1463, May 2025.
This graphical abstract illustrates a study where 43 adult patients (21 males, 22 females) underwent CT scans to reconstruct 3D pelvic models using Mimics and 3‐Matic software. The analysis measured the Lateral Compression II (LC‐II) screw path, revealing sex‐based anatomical differences that could improve the precision and safety of percutaneous LC‐II
Xingye Du, Yong Liu, Xuefeng Jiang
wiley   +1 more source

Comparative Efficacy of Posterior Versus Lateral Endoscopic Approaches in the Management of Complex Lumbar Disc Herniation: A Retrospective Cohort Study

Orthopaedic Surgery, EarlyView.
PEID and PETD both demonstrate favorable clinical efficacy in treating the three types of complex lumbar disc herniation while showing differences in the extent of decompression achieved. ABSTRACT Introduction Complex lumbar disc herniation (CLDH), including huge, migrated, and calcified variants, poses surgical challenges due to factors such as deep ...
Wentao Liu, Jialin He, Mingzhi Liu, Hongtao Ge, Guangyao Wan, Derong Xu, Chuanli Zhou   +6 more
wiley   +1 more source

Exploring Causal Associations Between Plasma Metabolites and Sciatica: A Two-Sample Mendelian Randomization Analysis. [PDF]

J Pain Res
Yu S, Wei Q, Luo Y, Wu G.
europepmc   +1 more source