Results 271 to 280 of about 51,210 (327)

Association between lipid-lowering agents with intervertebral disc degeneration, sciatica and low back pain: a drug-targeted mendelian randomized study and cross-sectional observation. [PDF]

Lipids Health Dis
Liu C, Chu X, Biao Y, Jin Q, Zhang Y, Gao Y, Feng S, Ma J, Zhang Y.   +8 more
europepmc   +1 more source

Oscillating gradient spin echo diffusion time effects implicate variations in neurite beading for the heterogeneous reduced diffusion in human acute ischemic stroke lesions

Magnetic Resonance in Medicine, Volume 94, Issue 5, Page 2158-2172, November 2025.
Abstract Purpose Monte Carlo simulations and short diffusion time measurements have suggested neurite beading and swelling as the underlying mechanism of reduced diffusion in acute stroke, although the observed diffusion time dependence is often heterogeneous and not yet fully understood.
Mi Zhou, Rob Stobbe, Matthew Budde, Brian Buck, Mahesh Kate, Mar Lloret, Paige Fairall, Ken Butcher, Ashfaq Shuaib, Derek Emery, Thorsten Feiweier, Christian Beaulieu   +11 more
wiley   +1 more source

Intradural Cauda Equina Metastasis of Colorectal Adenocarcinoma: A Case Report. [PDF]

Cureus
Chu CH, Wu WT, Yeh KT.
europepmc   +1 more source

Exercise Therapy Versus Manual Therapy for the Management of Pain Intensity, Disability, and Physical Function in People With Chronic Low Back Pain: A Systematic Review With Meta‐Analysis and Meta‐Regression

European Journal of Pain, Volume 29, Issue 8, September 2025.
ABSTRACT Background and Objective Guidelines recommend combining physical and psychological programmes for chronic low back pain (CLBP); however, exercise therapy (ET) and manual therapy (MT) are often delivered separately. This systematic review with meta‐analysis and meta‐regression of randomised controlled trials (RCTs) aimed to compare the efficacy
Luis González‐Gómez, Jose A. Moral‐Munoz, Abel Rosales‐Tristancho, Alejandro Cuevas‐Moreno, Melania Cardellat‐González, Álvaro‐José Rodríguez‐Domínguez   +5 more
wiley   +1 more source

Causality of genetically determined serum metabolites on lower back pain or/and sciatica: a comprehensive Mendelian randomized study. [PDF]

Front Pain Res (Lausanne)
Ren YM, Hou WY, Fan BY, Duan YH, Sun YB, Yang T, Zhang HJ, Sun TW, Tian MQ.   +8 more
europepmc   +1 more source

The mRNA Translation Inhibitor Vioprolide A Prevents Inflammatory Pain‐Like Behaviour With Limited Action on Already Established Pain‐Like Behaviour in Mice

European Journal of Pain, Volume 29, Issue 8, September 2025.
ABSTRACT Background Accumulating evidence indicates that pharmacological inhibition of the translational machinery is a therapeutic strategy for various diseases. However, whether inhibitors of mRNA translation might be suitable for pain therapy remains poorly understood. Here, we tested the potential analgesic effects of the natural product vioprolide
Patrick Engel, Tilman Gross, Gesine Wack, Rekia Sinderwald, Luisa Burgers, Robert Fürst, Achim Schmidtko   +6 more
wiley   +1 more source

Pseudo-Sciatica Pain Due to a Biceps Femoris Muscle Tear. [PDF]

Cureus
Correia R, Correia G, Meixedo S, de Castro Correia M, Carvalho JL.   +4 more
europepmc   +1 more source

Delivering the Message: Translating mRNA Therapy for Liver Inherited Metabolic Diseases

Journal of Inherited Metabolic Disease, Volume 48, Issue 5, September 2025.
ABSTRACT mRNA encapsulated in lipid nanoparticles (LNPs) provides a dual revolution in the field of gene therapy. mRNA brings fleeting efficacy and the possibility to adjust the therapy to clinical needs. LNP, as a non‐viral vehicle with flexible organ‐targeting, overcomes most immune complications of viral gene therapy. mRNA‐LNP has rapidly progressed
Sonam Gurung, Dany Perocheau, Roopkatha Ghosh, Stephen L. Hart, Julien Baruteau   +4 more
wiley   +1 more source

Rectum Perforation Complicated Necrotizing Fasciitis Present as Lumbar Disc Herniation: Case Report. [PDF]

J Acute Med
Ho TH, Ho SW.
europepmc   +1 more source

Perceptions of Low Back Pain and the Role of Physiotherapy in Bangladesh: A Qualitative Study

Musculoskeletal Care, Volume 23, Issue 3, September 2025.
ABSTRACT Background Low back pain (LBP) is a leading global cause of disability, with the most significant burden now observed in low‐ and middle‐income countries (LMICs). Despite the growing availability of physiotherapy, cultural perceptions and systemic factors may hinder its utilisation in Bangladesh.
Mohammad Ali, Casey L. Peiris, Jon J. Ford, Ahmed Hossain, Andrew J. Hahne   +4 more
wiley   +1 more source