Results 291 to 300 of about 24,748,805 (354)
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero+8 more
wiley +1 more source
Correction: Atomate2: modular workflows for materials science.
Ganose AM+55 more
europepmc +1 more source
Mendelian randomization identifies genetically predicted calorie dietary preference as causal risk factors for cancer. [PDF]
Zhang K+9 more
europepmc +1 more source
Science, Justice, Science Fiction: A Conversation with Kim Stanley Robinson [PDF]
Canavan, Gerry, Klarr, Lisa, Vu, Ryan
core +1 more source
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li+12 more
wiley +1 more source
Quality criteria for evaluating creative and interactive science dissemination in public outreach efforts: A scoping review. [PDF]
Van Even P, Zaman B, Hannes K.
europepmc +1 more source
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi+12 more
wiley +1 more source
Is a Hot Dog a Sandwich? Using Lateral Thinking to Teach Philosophy of Science. [PDF]
Kinnear B.
europepmc +1 more source