Results 241 to 250 of about 36,695,048 (298)

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

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Science and the Market for Technology

Management Science, 2021
Well-functioning markets for technology (MFT) allow inventors to sell their inventions to others that may derive more value from them. We argue that the growing use of science in inventions enhances MFT. Science-based inventions have higher gains from trade and lower transaction costs.
Ashish Arora, Sharon Belenzon, Jungkyu Suh   +2 more
openaire   +2 more sources

Attosecond Technology and Science

IEEE Journal of Selected Topics in Quantum Electronics, 2012
The generation of attosecond pulses has been the result of tremendous efforts and advances in the field of the interaction of ultrashort intense laser pulses with matter. Nowadays, the electric field waveform of femtosecond pulses can be precisely controlled and used to synthesize and measure the evolution in time of attosecond pulses.
SANSONE, GIUSEPPE, CALEGARI, FRANCESCA, NISOLI, MAURO   +2 more
openaire   +3 more sources

Science and Technology in India

Science, 1985
This assessment of the current status of science and technology in India focuses on developments in the areas of agriculture, energy, medicine, space, basic sciences, and engineering sciences. India has benefited in many fields from international collaboration during the last 30 years, but the country's leaders have also placed particularly strong ...
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Science and Technology for Development

Science, 1981
Science and technology are an integral part of international development, and it is important to convince our governments in the developed countries that money invested in science and technology in the Third World is for the mutual benefit of all.
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Medical Science and Technology

JAMA: The Journal of the American Medical Association, 1981
The intimate juxtaposition of science and technology—both often spoken of in the same breath—is currently threatened by those who view technological advances with mistrust. Nuclear fission and genetic engineering provoke almost as much apprehension among scientists as they do among laymen.
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Science, technology and purpose

AI & Society, 1992
In a recent book, ‘Machines with a Purpose’, many of the unattractive features of our technology were traced to a view of the world which has predominated in science for nearly four hundred years. This is, that nature, and everything that it contains, operates causally and without purpose.
openaire   +1 more source