Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi+3 more
wiley +1 more source
Measurement of the evolution of technology: A new perspective [PDF]
A fundamental problem in technological studies is how to measure the evolution of technology. The literature has suggested several approaches to measuring the level of technology (or state-of-the-art) and changes in technology. However, the measurement of technological advances and technological evolution is often a complex and elusive topic in science.
arxiv
Exploring assessment method of technological advancement based on literature cross-citation [PDF]
Assessing advancements of technology is essential for creating science and technology policies and making informed investments in the technology market. However, current methods primarily focus on the characteristics of the technologies themselves, making it difficult to accurately assess technologies across various fields and generations.
arxiv
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Regional Centres for Space Science and Technology Education (Affiliated to the United Nations) [PDF]
Education is a prerequisite to master the challenges of space science and technology. Efforts to understand and control space science and technology are necessarily intertwined with social expressions in the cultures where science and technology is carried out.
arxiv
Relationship between chlorophyll specific productivity and temperature at the surface in Sagami Bay, Japan [PDF]
Primary production was monthly measured from September 2001 to July 2003 at the surface in Sagami Bay, Japan. Thevariation in the primary production was primarily due to the variation in Pb (chlorophyll specific productivity).
Japan Agency for Marine-Earth Science and Technology+8 more
core
Making tau amyloid models in vitro: a crucial and underestimated challenge
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Can Science and Technology Capacity be Measured? [PDF]
The ability of a nation to participate in the global knowledge economy depends to some extent on its capacities in science and technology. In an effort to assess the capacity of different countries in science and technology, this article updates a classification scheme developed by RAND to measure science and technology capacity for 150 countries of ...
arxiv
A Cyberpunk 2077 perspective on the prediction and understanding of future technology [PDF]
Science fiction and video games have long served as valuable tools for envisioning and inspiring future technological advancements. This position paper investigates the potential of Cyberpunk 2077, a popular science fiction video game, to shed light on the future of technology, particularly in the areas of artificial intelligence, edge computing ...
arxiv
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze+3 more
wiley +1 more source