Results 131 to 140 of about 50,215,242 (280)

Business action for biodiversity via science-based targets for nature

The private sector has a critical role in achieving global biodiversity goals. The Science Based Targets Network (SBTN) provides a framework for companies to set quantitative targets to reduce their pressures on biodiversity and support its protection and restoration. These science-based targets (SBTs) for nature are grounded in scientific evidence, in
Masson, Alizée K. M., Prescott, Graham W., Beatty, Craig, Brooks, Sharon, Burgess, Neil, Cierna, Alena, Church, Rebekah, Flores, Nicole, Hyman, Amanda, Pynegar, Edwin, Roehrdanz, Patrick, Rogan, Jordan, Sonter, Laura J., Starkey, Malcolm, Stefanoudis, Paris V., Thomas-Smyth, Alice, Witkin, Taylor, Zvoleff, Alexander, Vijay, Varsha   +18 more
openaire   +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Green targets, green gains? The Financial Implications of Adopting Science-Based Targets

This study explores the financial implications of adopting Science-Based Targets (SBTs) under the Science-Based Targets initiative (SBTi), assessing whether SBT adoption reduces stock return volatility and benefits shareholders. The study employs a quantitative approach (2022–2025) with 1874 SBT-adopting firms and a control group of 6741 non-adopters ...
Lüdemann, Sven, Radakovic, Matteo
openaire   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Adopting science based targets – effects on mitigating freight transport emissions

An increasing number of corporations have adopted voluntary climate targets and seek verification of their ambitions through multi-stakeholder initiatives (MSIs).
Gustavsson Binder, Tobias,, Flodén, Jonas,, Schaad, Gabriela,   +2 more
core  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Pathway for Sustainable Aviation : Analysis of Science-Based Targets for Aviation

, 2023
In order for the aviation industry to meet the targets of the Paris agreement and reach net-zero by 2050, significant amounts of greenhouse-gas emissions are to be reduced. However, as the industry is essentially dependent on conventional jet fuel, it becomes necessary for alternative technologies to develop and phase out fossil-based fuels. The thesis
openaire   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source