Results 51 to 60 of about 796,919 (264)
Amphibious environments in Science Communication [PDF]
JCOM: Journal of Science Communication, 2005 The historian Marshall Berman wrote that living in modern times means "to find ourselves in an environment that promises us adventure, power, joy, growth, transformation [...] and, at the same time, that threatens to destroy everything we have ...
Castelfranchi Yurij
doaj
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Философия и космологияThe practically unlimited spread of pseudo-scientific and pseudo-expert assessments in today’s media generates an active social request for critical thinking, which can only rely on a scientifically based position.
Oleh Kubalskyi
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
International Journal of Communication, 2019 This article reviews the opportunities and challenges for computational research methods in the field of communication. Among the social sciences, communication stands out as a discipline with a relatively low-profile institutionalized focus on the in ...
Martin Hilbert +15 more
doaj
A community for disaster science [PDF]
Science, 2015 During disasters such as the 2010 Deepwater Horizon oil spill, engaging the expertise of the academic community helped responders make critical decisions. A major barrier to such engagement, however, is the cultural gap between academia's reward system and that which prevails in the disaster response community.
openaire +2 more sources