Results 41 to 50 of about 50,459 (259)
PLoS ONE, 2023 Undergraduate students studying Science, Technology, Engineering and Mathematics (STEM) often fail to persist in critical "gateway" courses, resulting in students leaving the STEM pathway.
Deann Leoni +2 more
doaj +1 more source
, 2022 Gateways provide access to computational codes as a service to their users. One popular design pattern is to use a single user account on an HPC system to run all workloads for the gateway’s user community. This introduces several security concerns for the owner of the user account, the machine, and the integrity of the workloads run by the gateway. In
Steven R. Brandt +2 more
openaire +3 more sources
Selection of computational environments for PSP processing on scientific gateways
Heliyon, 2018 Science Gateways have been widely accepted as an important tool in academic research, due to their flexibility, simple use and extension. However, such systems may yield performance traps that delay work progress and cause waste of resources or ...
Edvard Martins de Oliveira +5 more
doaj +1 more source
Lessons in immune adaptations to hypoxia revealed by comparative and evolutionary physiology
BMC Biology, 2023 Recent findings from comparative and evolutionary physiologists reveal novel insights into the regulation of inflammation and immune function under conditions of chronic-sustained and intermittent hypoxia.
Erica C. Heinrich, Michael S. Tift
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Ethics as a Gateway to Computer Science in Primary Education
Education in the Knowledge Society, 2017 This paper presents a proposal to bring ethics and ICT closer to students of the first courses of the primary education, supporting one in each other, following the Law “Real Decreto 126/2014, 28th of February”, which establishes the basic curriculum for
Juan Vicente OLTRA GUTIÉRREZ +2 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source