Results 281 to 290 of about 2,545,043 (343)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

Integrative analysis of GWAS, Bayesian fine-mapping, Mendelian randomization and colocalization reveals genetic determinants underlying milk-related traits in dairy cattle. [PDF]

open access: yesGenet Sel Evol
Teng J   +24 more
europepmc   +1 more source

scVMAP: a comprehensive platform for integrating single-cell chromatin accessibility regions with causal variants. [PDF]

open access: yesNucleic Acids Res
Yu ZM   +13 more
europepmc   +1 more source

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