Results 81 to 90 of about 872,028 (335)
Mapping knowledge with ontologies: the case of obesity [PDF]
arXiv, 2017 Scientometric techniques have been remarkably successful at mapping science but they face important difficulties when mapping research for societal problems possibly because they they are derived only from scientific documents and thus do not rely on non-academic expert knowledge.
arxiv
HerMES: SPIRE Science Demonstration Phase maps★†‡ [PDF]
Monthly Notices of the Royal Astronomical Society, 2010 9 pages, 9 figure, MNRAS Accepted, 27 Sept ...
James J. Bock +39 more
openaire +8 more sources
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source
Mapping the translational science policy ‘valley of death’ [PDF]
Clinical and Translational Medicine, 2013 AbstractTranslating the knowledge from biomedical science into clinical applications that help patients has been compared to crossing a valley of death because of the many issues that separate the bench from the bedside and threaten to stall progress. But translation is also inhibited by a science policy environment with its own impediments.
Eric M. Meslin +3 more
openaire +6 more sources
FEBS Letters, EarlyView.Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma +8 more
wiley +1 more source
Data Analysis for the Microwave Anisotropy Probe (MAP) Mission [PDF]
, 2000 We present an overview of the upcoming Microwave Anisotropy Probe (MAP) mission, with an emphasis on those aspects of the mission that simplify the data analysis. The method used to make sky maps from the differential temperature data is reviewed and we present some of the noise properties expected from these maps.
arxiv +1 more source
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
A new generation of science overlay maps with an application to the history of biosystematics [PDF]
arXiv, 2015 The paper proposes a text-mining based analytical framework aiming at the cognitive organization of complex scientific discourses. The approach is based on models recently developed in science mapping, being a generalization of the so-called Science Overlay Mapping methodology, referred to as Topic Overlay Mapping (TOM).
arxiv
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source