Results 161 to 170 of about 20,000,822 (310)
ARTS AND SCIENCE is published by the College of Arts and Science at Vanderbilt University in cooperation with the Office of Development and Alumni Relations Communications.Vanderbilt University.
Vanderbilt University. College of Arts and Science
core
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
ARTS AND SCIENCE is published by the College of Arts and Science at Vanderbilt University in cooperation with the Office of Development and Alumni Relations Communications.Vanderbilt University.
Vanderbilt University. College of Arts and Science
core
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
SciSciGPT: advancing human-AI collaboration in the science of science. [PDF]
Shao E +5 more
europepmc +1 more source
New ways of Communicating Science: Open Science and Open Access. [PDF]
Rocha EAV, Evora PRB.
europepmc +1 more source
ARTS AND SCIENCE is published by the College of Arts and Science at Vanderbilt University in cooperation with the Office of Development and Alumni Relations Communications.Vanderbilt University.
Vanderbilt University. College of Arts and Science
core
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source

