Results 261 to 270 of about 20,000,822 (310)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
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Proceedings of the ACM/IEEE Joint Conference on Digital Libraries in 2020, 2020
The rapid development of digital libraries and the proliferation of scholarly big data have created an unprecedented opportunity to explore scientific production and reward at scale. Fueled by the data exploration and computational advances in digital libraries, the science of science is an emerging multidisciplinary field that aims to quantify ...
Dashun Wang, Lu Liu
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The rapid development of digital libraries and the proliferation of scholarly big data have created an unprecedented opportunity to explore scientific production and reward at scale. Fueled by the data exploration and computational advances in digital libraries, the science of science is an emerging multidisciplinary field that aims to quantify ...
Dashun Wang, Lu Liu
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The science in computer science
Communications of the ACM, 2013Computer science is in a period of renaissance as it rediscovers its science roots.
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Advances in Health Sciences Education
In this editorial the editors reflect on issues raised by the special edition of the Journal on data science by asking the question: is data science in health professions education a 'science' as the term is generally understood? A series of criteria for science as a whole are applied to data science and the implications explored in the context of our ...
Rachel H, Ellaway, Patricia, O'Sullivan
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In this editorial the editors reflect on issues raised by the special edition of the Journal on data science by asking the question: is data science in health professions education a 'science' as the term is generally understood? A series of criteria for science as a whole are applied to data science and the implications explored in the context of our ...
Rachel H, Ellaway, Patricia, O'Sullivan
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Communications of the ACM, 2012
Researchers are exploring networked computational analysis, formal classification, and topic modeling to better identify relevant scientists, ideas, and trends.
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Researchers are exploring networked computational analysis, formal classification, and topic modeling to better identify relevant scientists, ideas, and trends.
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Philosophy of Science, History of Science, and Science of Science
1980The central topic of today’s meeting, cooperation between philosophy of science and history of science, is, to my mind, primarily a problem of professional interaction between philosophers and historians of science in studying some common object. It appears reasonable to emphasize this aspect to bring to the fore the research nature of the interaction
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