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Deciphering the Impact of RAC1‐SPTAN1 in ARPKD Cystogenesis Using Multifaceted Models
Advanced Science, EarlyView.Distal/connecting tubules expressing SLC8A1 have been suggested as a potential origin of ARPKD cysts. SPTAN1 has been identified as a key molecule in ARPKD cyst formation. Restoring SPTAN1 in PKHD1−/− organoids reduced cyst formation, normalized calcium levels, and decreased RAC1/c‐FOS expression, highlighting SPTAN1's role in ARPKD and the potential ...
Shohei Kuraoka +9 more
wiley +1 more source
Advanced Science, EarlyView.This study constructed the W1/O/W2 emulsion–based targeted therapy delivery system for ulcerative colitis (UC) utilizing LCC as surfactant for the first time. This multifunctional emulsion offered certain therapeutic advantages for UC, including targeted colonic delivery of active compounds, synergistic modulation of gut microbiota through combined ...
Qian Wu +9 more
wiley +1 more source
Discovering Interpretable Semantics from Radio Signals for Contactless Cardiac Monitoring
Advanced Science, EarlyView.This study presents a semantic representation framework for clinically interpretable cardiac monitoring from contactless radio signals. It formulates radio semantic learning as an information‐bottleneck problem and approximates the objective via intra‐modal compression and cross‐modal alignment, structuring radio measurements into meaningful semantic ...
Jinbo Chen +10 more
wiley +1 more source
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Science Policy and Science Policy Research
Nature, 1970This assessment of the value of science policy research in the making of policies is based on a lecture given at a meeting of the Sociology of Science Study Group of the British Sociological Association last March. The thoughts it contains are of course those of Dr Blume himself, and not of the Department of Education and Science or the Council for ...
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Science, 1982
Industry is now investing heavily and at an increasing rate in research and development. The government's responsibility should be to assure that this industrial spending is paralleled by real growth in its support of basic research. Such growth is realistic, even in times of budgetary constraints, given a proposed compact between the scientific ...
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Industry is now investing heavily and at an increasing rate in research and development. The government's responsibility should be to assure that this industrial spending is paralleled by real growth in its support of basic research. Such growth is realistic, even in times of budgetary constraints, given a proposed compact between the scientific ...
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“Science in Policy, Policy in Science”
Bulletin of the Atomic Scientists, 1964Statements on the federal investment in research and development, taken from the October 16, 1963 testimony of Dr. Wiesner (as Director of the Office of Science and Technology) before the House Subcommittee on Science, Research, and Development.
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Qualitative Health Research, 2007
Qualitative research struggles against a tide of quantitative methods. To assist in this struggle, it is useful to consider the historical and philosophical origins of quantitative methods as well as criticisms that have been raised against them. Although these criticisms have often been restricted to discussions in the philosophy of science, they ...
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Qualitative research struggles against a tide of quantitative methods. To assist in this struggle, it is useful to consider the historical and philosophical origins of quantitative methods as well as criticisms that have been raised against them. Although these criticisms have often been restricted to discussions in the philosophy of science, they ...
openaire +2 more sources