Results 51 to 60 of about 4,197,929 (308)
How has neoliberalism weakened science?
Natures Sciences Sociétés, 2021 The current Covid-19 pandemic, and before that, the environmental crisis due to climate change, raise major questions about the relationship between science and society.
Davi Hendrik +3 more
doaj +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
eLife, 2018 In an era in which evidence is being disregarded, scientists need to speak up in support of the pursuit for truth.
Eve Marder
doaj +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Frontiers in Research Metrics and Analytics, 2018 When assessing the importance of materials (or other components) to a given set of applications, machine analysis of a very large corpus of scientific abstracts can provide an analyst a base of insights to develop further.
Nikhil Kalathil +4 more
doaj +1 more source
Publications, 2023 Open access (OA) has become a critical issue in science policy and affects a wide range of activities in universities and research labs. Research-performing organizations (RPOs), defined as publicly funded universities and research institutions, face ...
Heinz Pampel
doaj +1 more source
Aging and Cancer, EarlyView.ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef +2 more
wiley +1 more source
Carrying on \u27Korematsu:\u27 Reflections on My Father\u27s Legacy [PDF]
, 2015 Climate change and the sea level rise that it contributes to is an ever more pressing issue for costal municipalities around the world. Today there is a great deal of scientific reports and projections on what these changes could entail.
Korematsu, Karen
core +1 more source
Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham +7 more
wiley +1 more source
Five suggestions for substantial NIH reforms
eLife, 2016 The National Institutes of Health needs to make radical changes to ensure that biomedical research continues to thrive in the United States.
Michael Rosbash
doaj +1 more source