Results 31 to 40 of about 9,574 (187)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Processus de constitution des rôles managériaux dans la formation de la stratégie – une lecture ancrée dans la théorie des représentations sociales [PDF]

open access: yes
Plusieurs travaux de recherche récents invitent à considérer les rôles majeurs des managers dirigeants et intermédiaires au sein du processus de formation de la stratégie.
F. Grazzini
core  

Facteurs associés à la détresse psychologique des étudiants: mieux comprendre pour mieux intervenir [PDF]

open access: yes, 2019
PAREA n°PA-2016-006La présente recherche a été subventionnée par le ministère de l'Éducation et de l'Enseignement supérieur dans le cadre du Programme d'aide à la recherche sur l'enseignement et l'apprentissage (PAREA).Comprend des références ...
Gingras, Hélène   +2 more
core  

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Éducation thérapeutique du patient. Modèles, pratiques et évaluation [PDF]

open access: yes, 2010
International audienceIssu d’une collaboration entre l’Inpes et des acteurs de l’éducation thérapeutique du patient, cet ouvrage rassemble des analyses d’interventions d’éducation thérapeutique mises en place en France et au Québec, dans le cadre de huit
Balcou-Debussche, Maryvette   +3 more
core   +3 more sources

Expliquer, dépister et traiter médicalement les troubles du comportement des enfants et des adolescents [PDF]

open access: yes, 2007
L’INSERM a publié en France un rapport, Trouble des conduites chez l’enfant et l’adolescent, qui est ici abordé comme un cas type. Nous faisons une hypothèse selon laquelle le modèle biopsychologique véhiculé dans ce rapport représente bien les nouveaux ...
Lafortune, Denis
core   +1 more source

Impact of a senior research thesis on students' perceptions of scientific inquiry in distinct student populations

open access: yesFEBS Open Bio, EarlyView.
This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart   +4 more
wiley   +1 more source

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