Results 41 to 50 of about 4,974,237 (279)

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Special Distribution of Discourse Markers Determined by Genre-Specific Scientific Discourse

open access: yesИзвестия Южного федерального университета: Филологические науки, 2017
The article is concerned with the role of discourse markers in denoting the genre of some text or utterance. The analysis is based on proper scientific discourse, including such genres as a monograph, article, lecture and discussion.
Olesya A. Zagorodnova
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Academic Writing: A Discipline or Disciplines?

open access: yesВысшее образование в России, 2021
In the last five years, the discipline “Academic Writing” in one form or another has become part of the programs of many Russian universities. The goal of the discipline is the achievement of academic literacy.
I. M. Zashikhina
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

SCHEDULE OF SCIENTIFIC ACTIVITIES

open access: yes, 2020
Schedule of scientific ...
Article Editorial
core   +1 more source

Bisubstantive sentences in scientific discourse: Types of evaluation in scientific articles [PDF]

open access: yesИзвестия Саратовского университета. Новая серия: Серия Филология, Журналистика
The article analyzes general and specific types of evaluation actualized in bisubstantive sentences in scientific articles in various specialties. It is noted that bisubstantive sentences are a productive means of expressing evaluative meaning.
Vatina, Anastasia Евгеньевна
doaj   +1 more source

The research of the surface and deep scientific articles structures by Russian-speaking authors based on the linguocultural approach

open access: yesВестник Тамбовского университета. Серия: Гуманитарные науки, 2023
Importance. Academic writing courses, traditionally based on the concept of English for Academic Purposes, are increasingly being criticized by researchers and teachers of this discipline. Teaching students to write scientific articles that correspond to
E. Е. Plokhikh
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

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