Results 41 to 50 of about 4,974,237 (279)
Tau acetylation at K331 has limited impact on tau pathology in vivo
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Special Distribution of Discourse Markers Determined by Genre-Specific Scientific Discourse
The article is concerned with the role of discourse markers in denoting the genre of some text or utterance. The analysis is based on proper scientific discourse, including such genres as a monograph, article, lecture and discussion.
Olesya A. Zagorodnova
doaj +1 more source
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Academic Writing: A Discipline or Disciplines?
In the last five years, the discipline “Academic Writing” in one form or another has become part of the programs of many Russian universities. The goal of the discipline is the achievement of academic literacy.
I. M. Zashikhina
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
SCHEDULE OF SCIENTIFIC ACTIVITIES
Schedule of scientific ...
Article Editorial
core +1 more source
Bisubstantive sentences in scientific discourse: Types of evaluation in scientific articles [PDF]
The article analyzes general and specific types of evaluation actualized in bisubstantive sentences in scientific articles in various specialties. It is noted that bisubstantive sentences are a productive means of expressing evaluative meaning.
Vatina, Anastasia Евгеньевна
doaj +1 more source
Importance. Academic writing courses, traditionally based on the concept of English for Academic Purposes, are increasingly being criticized by researchers and teachers of this discipline. Teaching students to write scientific articles that correspond to
E. Е. Plokhikh
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An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source

