Results 61 to 70 of about 2,445,433 (252)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

MENINGKATKAN KUALITAS PENULISAN KARYA ILMIAH GURU-GURU SEKOLAH MENENGAH ATAS DI PARAKAN TEMANGGUNG

Rekayasa, 2016
Partners of this community service wereMadrasah Aliyah Negeri Parakan and SMK 17 Parakan Temanggung, Temanggung. This community serviceactivity was aimed atovercoming some of the problems faced by the teachers in both partners related to improving the ...
Rochmad Rochmad, Arief Agoestanto, Muhammad Kharis   +2 more
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

ECOLOGICAL CHEMISTRY THROUGH POPULAR SCIENTIFIC ARTICLES

Studia Universitatis Moldaviae: Stiinte reale si ale naturii, 2017
CHIMIA ECOLOGICĂ ÎN ARTICOLELE ȘTIINȚIFICO-POPULARE  Popularizarea Chimiei ecologice este scopul articolelor științifico-populare, care sunt publicate în reviste online pentru profesori.
USM ADMIN
doaj   +2 more sources

Study of the Academic Members Attitude about Main Factors of Not Approaching to Scientific Writing in Hamadan University of Medical Sciences

پزشکی بالینی ابن سینا, 2008
Background & Objective: one of the important indicators of scientific study and science production in the universities is original research and its scientific article.
Masoud Koorki, Hosein Mahjub, Nasrin Sheikh   +2 more
doaj  

Lost in translation

Клиническая и экспериментальная тиреоидология, 2017
Along with globalization and the development of the Internet, new phenomenon have appeared and multiplied: international open access (OA) scientific journals in which manuscripts can be published for a fee. It should be stipulated that the bulk of the OA
Grigory A. Gerasimov
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

ChatGPT in Writing Scientific Articles: Friend or Foe? [PDF]

Journal of Medical Education and Development
Artificial intelligence tools such as GBT Chat have sparked many discussions among academics; While some see them as a useful tool to speed up research and others see it as a threat to the integrity of authorship.
Safiyehsadat Heydari
doaj  

A Comparative Study of Factors Affecting Reluctance to Scientific Writing from The Viewpoints of Basic and Clinical Sciences Faculty Members in Hamedan University of Medical Sciences in 2006 [PDF]

مجله ایرانی آموزش در علوم پزشکی, 2008
Introduction: Although activities carried out in Hamedan University of Medical Sciences in regard to publishing scientific articles are appreciable, they are not gratifying yet.
Hossein Mahjub, Masoud Koorki, Nasrin Sheikh   +2 more
doaj  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source