Results 41 to 50 of about 9,101,925 (291)

Science Collaboration for Capacity Building: Advancing Technology Transfer Through a Treaty for Biodiversity Beyond National Jurisdiction

Frontiers in Marine Science, 2020
Marine technology transfer and capacity building are key elements in the development of a historic new agreement for the conservation and sustainable use of marine biodiversity in areas beyond national jurisdiction (BBNJ agreement) under the United ...
Harriet Harden-Davies, Paul Snelgrove
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Applying a Capacity-Results Framework in Lao PDR and Other Pilot Countries

, 2005
Achieving the Millennium Development Goals (MDG) and poverty reduction objectives of developing countries requires a substantially greater investment in capacity development. This translates into action at three
Hart-Poliquin, Moira, Alameddine, Chirine   +1 more
core   +1 more source

Academic Writing Empowerment: Pendampingan Penulisan dan Publikasi Artikel Ilmiah bagi Dosen dan Tenaga Akademik

Dharma
Perguruan tinggi memiliki peran strategis dalam meningkatkan kualitas sumber daya manusia melalui pelaksanaan tridharma. Namun, masih banyak ditemui dosen dan tenaga akademik yang menghadapi kendala dalam penulisan dan publikasi artikel ilmiah.
Moh. Wardi, Supandi Supandi, Heri Fadli Wahyudi, Ismail Ismail, Juhairiyah Juhairiyah, Siti Nur Aisyah, Siti Masriyah   +6 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Investigation and analysis of the current situation of research capacity of professional graduates majoring in neurosurgery [PDF]

Jichu yixue yu linchuang
Objective In order to provide reference and basis for the scientific research capacity training of medical graduates, the current situation training for professional graduates majoring in neurosurgery was investigated and analyzed.
LIU Zhenlei, JIAN Fengzeng, WU Hao
doaj   +1 more source

Inconsistencies in legal and scientific perspectives on adolescents' capacities [PDF]

Advances in Psychiatric Treatment, 2011
SummaryThe US Supreme Court's complaint in 2005 about inconsistencies in research into adolescents' decision-making capacity did not take into account the different demands placed on adolescents by controlled situations and unstructured situations. Apparent inconsistencies in research into adolescents' capacity in treatment situations and in trial ...
openaire   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source