Results 51 to 60 of about 320,267 (252)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Collaboration Diversity and Scientific Impact

CoRR, 2018
The shift from individual effort to collaborative output has benefited science, with scientific work pursued collaboratively having increasingly led to more highly impactful research than that pursued individually. However, understanding of how the diversity of a collaborative team influences the production of knowledge and innovation is sorely lacking.
Yuxiao Dong, Hao Ma 0001, Jie Tang 0001, Kuansan Wang   +3 more
openaire   +2 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

The structure of scientific collaboration networks in Scientometrics [PDF]

Scientometrics, 2007
The structure of scientific collaboration networks in scientometrics is investigated at the level of individuals by using bibliographic data of all papers published in the international journal Scientometrics retrieved from the Science Citation Index (SCI) of the years 1978–2004.
Hou, Haiyan, Kretschmer, Hildrun, Liu, Zeyuan   +2 more
openaire   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Collaborative exploration of 3D scientific data [PDF]

Proceedings of the 2008 ACM symposium on Virtual reality software and technology, 2008
This demonstration introduces new ways for exploring Collaborative Virtual Environments (CVE) that contain 3D scientific data sets obtained by simulation. In order to make decisions accordingly to their collective knowledge and understanding of the simulation, the users must collaborate and share experiences and comments.
Duval, Thierry, Fleury, Cédric, Nouailhas, Bernard, Aguerreche, Laurent   +3 more
openaire   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

The effect of collaborators on institutions’ scientific impact [PDF]

Scientometrics, 2016
The effect of collaborators on institutions scientific impact was examined for 81 institutions with different degrees of impact and collaboration. Not only collaborators including both core and peripheral collaborators cite each other more than non-collaborators, but also the first group cites each other faster than the second group even when self ...
Ali Gazni, Vincent Larivière, Fereshteh Didegah   +2 more
openaire   +3 more sources

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source