Results 61 to 70 of about 6,281,305 (271)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Scientific Community

Epistemology & Philosophy of Science
This article problematizes the state of the contemporary scientific community, which fluctuates between the desire for autonomy and creative freedom, on the one hand, and responsibility to social challenges, on the other. In this context, the social meaning of Paul Feyerabend’s epistemological anarchism is reconstructed, revealing not only critical but
Ilya T. Kasavin, Olga E. Stoliarova
openaire   +3 more sources

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

From statistical bibliography to bibliometrics: development of a quantitative approach to the research of the written word

Libellarium: Journal for the Research of Writing, Books, and Cultural Heritage Institutions, 2010
The author’s intention in this paper is to inform the broader public of the historical development and major concepts of bibliometrics as an area of quantitative study of written communication, which today applies a set of modern methods and techniques ...
Franjo Pehar
doaj   +1 more source

Farewell to Bright-Line: A Guide to Reporting Quantitative Results Without the S-Word

Frontiers in Psychology, 2020
Recent calls to end the practice of categorizing findings based on statistical significance have focused on what not to do. Practitioners who subscribe to the conceptual basis behind these calls may be unaccustomed to presenting results in the nuanced ...
Kevin M. Cummins, Kevin M. Cummins, Kevin M. Cummins, Charles Marks   +3 more
doaj   +1 more source

Effectiveness of local wisdom integrated (LWI) learning model to improve scientific communication skills of junior high school students in science learning

Journal of Physics: Conference Series, 2019
The previous research has been developed Local Wisdom Integrated (LWI) Learning Model and has been declared that it is valid to improve problem solving skill, scientific communication skills, and environmental care attitude of junior high school students.
I. N. Dewi, M. Ibrahim, S. Poedjiastoeti, B. Prahani*, D. Setiawan, S. Sumarjan   +5 more
semanticscholar   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Open access – deus ex machina for publishing scholarly journals?

Libellarium: Journal for the Research of Writing, Books, and Cultural Heritage Institutions, 2015
The article describes the evolution of scholarly communication through scholarly journals. It gives a short overview of the historical development, starting from the first journals in the 17th century to problems in the 20th century (such as increase in ...
Ivana Hebrang Grgić
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source