Results 41 to 50 of about 482,768 (286)

2017 Scientific Consensus Statement: land use impacts on the Great Barrier Reef water quality and ecosystem condition, Chapter 5: overview of key findings, management implications and knowledge gaps [PDF]

, 2017
To support the development of the Reef 2050 Water Quality Improvement Plan 2017-2022, a multidisciplinary group of scientists, with oversight from the Reef Independent Science Panel, was established to review and synthesise the significant advances in ...
Bartley, Rebecca, Thorburn, Peter, Ronan, Mike, Taylor, Bruce, Waterhouse, Jane, Schaffelke, Britta, Brodie, Jon, Eberhard, Rachel, Star, Megan, Rolfe, John, Kroon, Frederieke   +10 more
core  

Recently acquired and early chronic hepatitis C in MSM: Recommendations from the European treatment network for HIV, hepatitis and global infectious diseases consensus panel.

, 2020
: In response to growing evidence of an expanding epidemic of sexually acquired hepatitis C virus (HCV) infection in HIV-positive MSM, the European AIDS Treatment Network (NEAT) acute hepatitis C consensus panel developed their first recommendations for ...
Consensus Panel, European Treatment Network for HIV, Hepatitis and ...
core   +1 more source

Models of Scientific Consensus

, 2023
The beginnings of modern philosophy are routinely depicted as a break with tradition and authority, as a moment when the individual mind took charge of its own powers, shedding itself of idols and scholastic prejudices, adopting new criteria of certain truth either proper to the mind or based on direct observation and experience.
openaire   +2 more sources

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

2017 Scientific Consensus Statement: land use impacts on the Great Barrier Reef water quality and ecosystem condition. Chapter 4: management options and their effectiveness [PDF]

, 2017
This chapter seeks to answer the following questions: 1. What are the values of the Great Barrier Reef? 2. How effective are better agricultural practices in improving water quality? 3.
Silburn, Mark, McCosker, Kevin, Davis, Aaron, Taylor, Bruce, Selles, Amelia, Rolfe, John, Star, Megan, Thorburn, Peter, Flint, Nicole, Ronan, Mike, Lyons, Pethie, Marshall, Nadine, Griffiths, Matthew, Kroon, Frederieke, Bartley, Rebecca, Gunn, John, Lewis, Stephen, Poggio, Mark, Wilkinson, Scott, Windle, Jill, Webber, Tony, Hill, Rosemary, Maclean, Kirsten, Robinson, Cathy, Adame, Fernanda, Eberhard, Rachel   +25 more
core  

Modeling Innovations: Levels of Complexity in the Discovery of Novel Scientific Methods

Philosophies
Scientists often disagree on the best theory to describe a scientific event. While such debates are a natural part of healthy scientific discourse, the timeframe for scientists to converge on an ideal method may not always align with real-life knowledge ...
José Ferraz-Caetano
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Open Questions in Scientific Consensus Messaging Research

, 2020
In recent years, there has been considerable interest in studying and using scientific consensus messaging strategies to influence public opinion. Researchers disagree, sometimes vociferously, about how to examine the potential influence of consensus ...
Asheley R. Landrum, Matthew H. Slater
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source