Results 211 to 220 of about 3,110,040 (260)

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Scientific data services

Proceedings of the first annual workshop on High performance computing meets databases, 2011
As high-performance computing approaches exascale, the existing I/O system design is having trouble keeping pace in both performance and scalability. We propose to address this challenge by adopting database principles and techniques in parallel I/O systems.
Wu, Kesheng   +3 more
openaire   +1 more source

Using Nazi Scientific Data

Dialogue, 1986
In a series of experiments done in wartime Nazi Germany, inmates of the Dachau concentration camp were exposed to cold by being immersed in ice water, or kept outside in freezing temperatures; their responses were measured, and various techniques were used in an attempt to revive them.
openaire   +2 more sources

Mining scientific data

2002
Abstract The past two decades have seen rapid advances in high-performance computing and tools for data acquisition in a variety of scientific domains. Coupled with the availability of massive storage systems and fast networking technology to manage and assimilate data, these have given a significant impetus to data mining in the scientific domain ...
Naren Ramakrishnan, Ananth Y. Grama
openaire   +1 more source

Sharing scientific data

Communications of the ACM, 1990
The willingness of one scientist to share data with another scientist continues to be influenced by a number of enconomic, social, psychological and political factors.
Theodor D. Sterling, James J. Weinkam
openaire   +1 more source

Open Scientific Data

2023
Not opening scientific data is costly. It has been estimated that a significant share of scientific knowledge disappears every year. In a 2014 study less than half of biological datasets from the 1990s have been recovered and when possible the recovery has necessitated significant time and efforts.
openaire   +1 more source

Scientific data repositories

Proceedings of the 2003 ACM SIGMOD international conference on Management of data, 2003
Managing scientific data warehouses requires constant adaptations to cope with changes in processing algorithms, computing environments, database schemas, and usage patterns. We have faced this challenge in the RHESSI Experimental Data Center (HEDC), a datacenter for the RHESSI NASA spacecraft.
Etzard Stolte   +3 more
openaire   +1 more source

Scientific Data Analysis

2015
Scientific Data Analysis consists of two parts. Part I covers how to understand the statistics in scientific data analysis. It looks at statistical concepts, regression analysis, hypothesis testing, and comparing data. Part II looks at analysing experimental data. Within this part, the topics of project data analysis, single response
openaire   +1 more source

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