Results 51 to 60 of about 3,110,040 (260)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
, 2016 Issues de l’expérience, les données constituent une description brute du réel, sur le fondement desquelles s’élaborent ou se vérifient les théories scientifiques. Or, à l’étude, les interactions entre cet élément de base de la connaissance et l’ordre juridique peuvent être observées à trois stades.
openaire +3 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Lundisim: Model Meshes for Flow Simulation and Scientific Data Compression Benchmarks
Geoscience Data JournalThe volume of scientific data produced for and by numerical simulation workflows is increasing at an incredible rate. This raises concerns either in computability, interpretability, and sustainability.
Laurent Duval +3 more
doaj +1 more source
Tissue-like P system for Segmentation of 2D Hexagonal Images
ARO-The Scientific Journal of Koya University, 2016 Membrane computing, which is a new computational model inspired by the structure and functioning of biological cells and by the way the cells are organized in tissues. MC has been adopted in many real world applications including image segmentation.
Rafaa I. Yahya +3 more
doaj +1 more source
The Clinical Respiratory Journal, 2023 Background Oral selexipag, a prostacyclin pathway agent (PPA), is effective in patients with pulmonary arterial hypertension (PAH). The objective of this study is to assess the impact of initiating oral selexipag within 12 months of diagnosis on health ...
Yuen Tsang +4 more
doaj +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
TOPOGRAPHIC-GEODETIC AND CARTOGRAPHIC SUPPORT OF THE ARCTIC ZONE OF THE RUSSIAN FEDERATION
Записки Горного института, 2018 A version of the project of the concept of topographic, geodetic and cartographic support of the Arctic zone of the Russian Federation based on the use of modern means and tools is presented, including its content.
M. G. Mustafin +5 more
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source