Results 71 to 80 of about 3,110,040 (260)

Physical activity, sedentary time and physical capability in early old age: British birth cohort study.

PLoS ONE, 2015
PurposeTo investigate the associations of time spent sedentary, in moderate-to-vigorous-intensity physical activity (MVPA) and physical activity energy expenditure (PAEE) with physical capability measures at age 60-64 years.MethodsTime spent sedentary ...
Andrew J M Cooper, Rebecca K Simmons, Diana Kuh, Soren Brage, Rachel Cooper, NSHD scientific and data collection team   +5 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

An end-to-end mass spectrometry data classification model with a unified architecture

Scientific Reports
Mass spectrometry, known for its high sensitivity, selectivity, rich structural information, and rapid analysis capabilities, is widely used in disease diagnosis and bioanalysis. Despite progress in classification methods/tools for data collection in the
Yinchu Wang, Wei Zhang, Lin Guo, Fengyi Zhang, Zilong Liu, Xingchuang Xiong, Xiang Fang   +6 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Usability testing on intelligent mobile web pre-fetching of cloud storage scheme

IJAIN (International Journal of Advances in Intelligent Informatics), 2017
Mobile device and Cloud Storage (CS) represent the trends of technology usage of the last few years. However, the difficulty in managing the data when there are too many simultaneous uses of cloud storage services at the same time that can cause latency ...
Nur Syahela Hussien, Sarina Sulaiman, Siti Mariyam Shamsuddin   +2 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Data Mining and Scientific Data

Arctic, Antarctic, and Alpine Research, 2005
Abstract Data mining—the discovery of previously unknown information from a large collection of individual data sources—is becoming increasingly popular for scientific data archives. We describe an approach to data mining that uses spatial, temporal, and type constraints to obtain a broad list of data that are potentially related to a data set of ...
Ben Raymond, David J. Watts, Harry Burton, Jeremy Bonnice   +3 more
openaire   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Patterns of leisure-time physical activity participation in a British birth cohort at early old age.

PLoS ONE, 2014
Using data from a nationally representative British birth cohort we characterized the type and diversity of leisure-time physical activity that 2,188 participants (age 60-64 years) engaged in throughout the year by gender and obesity.
Kathryn R Martin, Rachel Cooper, Tamara B Harris, Soren Brage, Rebecca Hardy, Diana Kuh, NSHD Scientific and Data Collection Team   +6 more
doaj   +1 more source