Results 131 to 140 of about 909,869 (300)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Is scientific assessment a scientific discipline?: A reflection paper on EFSA, the European Food Safety Authority. [PDF]

EFSA J, 2017
Deluyker H.
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Rachunkowość jako dyscyplina naukowa

Zeszyty Teoretyczne Rachunkowości, 2010
Zagadnienie umiejscowienia rachunkowości wśród dyscyplin naukowych jest przedmiotem analiz zawartych w artykule. Do nauk typu science (inaczej przyrod-niczych) należą dyscypliny, w których odkrywa się i respektuje fundamentalne prawa natury.
Mieczysław Dobija
doaj  

Optimization of crop residue management practice to improve soil aggregation and mineral-associated organic carbon in a clay soil of Bangladesh

Waste Management Bulletin
Organic matter application is considered an important option to increase soil aggregate formation and mineral-associated organic carbon (MAOC) in soil. In south Asia, different conventional strategies of soil management are used to improve soil quality ...
Abdullah-Al-Mamun, Sonia Nasrin, Saria Afrin, Walid Hossain, Mahbub Ul Islam, Faridul Islam, M. Ahasanur Rabbi, Milton Halder   +7 more
doaj   +1 more source

Environmental epigenetics: from novelty to scientific discipline. [PDF]

J Appl Toxicol, 2014
Burris HH, Baccarelli AA.
europepmc   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Medical Informatics as Academic and Scientific Discipline in Bosnia and Herzegovina - Twenty Five Years of Experiences from Faculty of Medicine, University of Sarajevo. [PDF]

Acta Inform Med, 2017
Masic I.
europepmc   +1 more source

ENVIRONMENTAL HAZARDS OF FARMING: THINKING ABOUT THE MANAGEMENT CHALLENGE [PDF]

What an economist argues about managing the hazards of new production technologies depends on that individual's beliefs about the scientific credibility of assessed risk of new technologies, about the meaning of voluntary risk and compensations, and ...
Shabman, Leonard A.
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source