Results 101 to 110 of about 728,635 (308)

Regulation and Characteristics of Reserving Budget Funds in Russian Regions

open access: yesРегионология
Introduction. The relevance is due to the fact that very little attention is paid to this topic in domestic papers despite the importance of reserving budget funds as an instrument of countercyclical policy and sustainability of regional development. The
Evgeniy N. Timushev, Vita A. Yagovkina
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

The Genevese transboundary aquifer (Switzerland-France): The secret of 40 years of successful management

open access: yesJournal of Hydrology: Regional Studies, 2018
The Genevese aquifer is used for the supply of drinking water harnessed from ten wells on the Swiss side and four on the French side. During the 1960s and 1970s, overpumping lowered the groundwater level by more than 7 m, thereby depleting about one ...
Gabriel de los Cobos
doaj   +1 more source

Partnerships for Parks [PDF]

open access: yes, 1999
Looks at how partnerships for parks are successfully combining the assets of the public and private sectors in novel ways to create new and refurbished parks, greenways, trails, and other community assets in cities across the U ...
Christoper Walker
core  

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

All-Union Society of Inventors and Innovators in System of State Policy, Aimed at Accelerating Scientific-Technical Progress in the Late 1950’s - Early 1960-ies (by Example of Activities of AUSII Tatar Regional Council)

open access: yesНаучный диалог, 2017
The article is devoted to the activities of the Tatar regional branch of the all-union society of inventors and innovators (AUSII) in the context of the implementation of scientific and technical policy of the state aimed at accelerating scientific ...
D. A. Pinayeva
doaj   +1 more source

Strengthening the management of scientific research funds and improving the efficiency of scientific research funds [PDF]

open access: yesProceedings of the 2017 3rd International Conference on Economics, Social Science, Arts, Education and Management Engineering (ESSAEME 2017), 2017
Xianjiao Liu, Yang Yu
openaire   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

open access: yesFEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini   +2 more
wiley   +1 more source

Fundamentals of Ukrainian land fund management [PDF]

open access: yesMarketing i Menedžment Innovacij, 2016
The aim of the article. The establishment of a land-use rational system, based on the effective state regulation of the Ukrainian Land Fund, is one of the main state tasks to solve problems in land resources and environmental management.
V.Yu. Shkola   +3 more
doaj  

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