Results 81 to 90 of about 6,019,206 (249)

System Analysis as Scientific Inquiry [PDF]

, 2008
Information systems are understood as models or representations of an application domain. System analysis is a mode of inquiry for purposes of understanding the domain and effecting change in it.
Evermann, Joerg, Mistry, Riddhi
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Efforts to Improve Scientific Literacy of Students through Guided Inquiry Learning Based on Local Wisdom of Baduy’s Society

Jurnal Penelitian dan Pembelajaran IPA, 2017
The aim of this study was to determine the influence of guided inquiry learning model toward the improvement of students’s scientific literacy in integrated science learning on environmental conservation concept based on local wisdom of Baduy’s society ...
Asep Saefullah, Udi Samanhudi, Lukman Nulhakim, Liska Berlian, Aditya Rakhmawan, Bai Rohimah, R. Ahmad Zaky El Islami   +6 more
doaj   +1 more source

Deliberative inquiry: Integrated ways of working in children services [PDF]

, 2010
In striving for greater integration of children services across a number of government and non government agencies, this paper examines the effect of drawing on deliberative inquiry as the lever for realising greater alignment across agencies.
Linda Lee-Davies, Nick Johnson, Kakabadse, Nada K, Nada K. Kakabadse, Johnson, Nick, Kakabadse, Andrew P., Lee-Davies, Linda, Kakabadse, Andrew P, Andrew Kakabadse, Kakabadse, Nada K.   +9 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Effects of scaffolds and scientific reasoning ability on web-based scientific inquiry

International Journal of Contemporary Educational Research, 2016
This study examined how background knowledge, scientific reasoning ability, and various scaffolding forms influenced students’ science knowledge and scientific inquiry achievements.
Hui-Ling Wu, Hsiao-Lan Weng
doaj  

Philosophical Inquiry to Advance Cosmopolitan Engagement

, 2012
Il progetto intende promuovere lo sviluppo di attitudini, competenze, stili di pensiero caratterizzati dalla capacità di essere riflessivamente consapevoli delle proprie radici e della propria identità e allo stesso tempo di aprirsi al nuovo e al ...
Camhy D., Garcia Moriyon F., Glaser J., STRIANO, MAURA   +3 more
core  

Re-thinking missions ; a laymen's inquiry after one hundred years, by the Commission of appraisal, William Ernest Hocking, chairman. [PDF]

, 1932
http://www.archive.org/details ...
Laymen's Foreign Missions Inquiry. Commission of Appraisal., Laymen's Foreign Missions Inquiry. Commission of Appraisal   +1 more
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