Results 111 to 120 of about 8,315,700 (303)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

India and Pakistan 1:250,000 [cartographic material] /

, 1959
Various eds. Topographic map series of India and Pakistan showing populated places, railroads, boundaries and roads. Relief shown by contours and spot heights.
United States. Army Map Service.
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Pengaruh LKPD Berbasis Inkuiri Berbantuan Peta Vee Terhadap Kemampuan Penalaran Ilmiah Siswa pada Pembelajaran IPA di SMP

Pendipa
Tujuan utama penelitian ini adalah untuk mengetahui pengaruh LKPD berbasis inkuiri berbantuan peta Vee terhadap kemampuan penalaran ilmiah siswa pada pembelajaran IPA di SMP.
Elmi Yuniarti, Supeno, Nur Ahmad
doaj   +1 more source

Manchuria 1:250,000 [cartographic material] /

, 1950
Various eds. "Constructed and molded in 1950 from Manchuria 1:250,000."; Each sheet is named and numbered individually.; Includes glossary and index to adjacent sheets.; Place names in Chinese and Wades Giles romanisation.; Topographic raised relief ...
United States. Army Map Service.
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Le temps long d’une carte scientifique urbaine : l’Oncopole de Toulouse et Toulouse Aerospace

Carnets de Géographes
The article evokes the constitution of the scientific map of Toulouse. The establishment of scientific institutions is the product of complex historical processes, mobilizing very profuse political imaginations.
Jérôme Lamy, Josselin Tallec
doaj   +1 more source

Indochina 1:100,000 [cartographic material] /

, 1950
Various eds. Map series of Indochina showing roads, railways, canals, international and provincial boundaries, villages, churches, ruins, forest reserves, vegetation and cultivation. Relief shown by contours and spot heights.; "Copied ... from Carte de l'
United States. Army Map Service.
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Truk Islands : special strategic map

, 1945
Scale 1:1,000,000 ; Lambert conformal conic projection. 1 map : color ; 46 x 68 cm. First edition-AMS 1. Prepared under the direction of the Chief of Engineers, U.S. Army ; compiled by the Army Map Service, February 1943. Standard map series designation:
United States. Army Map Service.
core   +1 more source