Results 191 to 200 of about 8,315,700 (303)

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Microstructure and Texture Evolution of GWS841 Magnesium Alloy During Hot Extrusion. [PDF]

Materials (Basel)
Yan L, He S, Su G, Feng Z, Wang N, Zheng H, Li Z.   +6 more
europepmc   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Map of the city of Melbourne [cartographic material] : including the municipalities of Emerald Hill & Collingwood ... /

Map 282 from Ferguson Collection.; Map shows streets, railways, buildings, parks and reserves, and names wards.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.map-f282; Library copy folded to 16.8 x 11.5 ...
Mason, Cyrus, 1830-1915.
core  

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

MAP-Derived Shock Index for Point-of-Care Physiological Risk Stratification After CT-Confirmed Cervical Spine Fracture: Development and Internal Validation of a Prognostic Model for In-Hospital Mortality. [PDF]

Diagnostics (Basel)
Pepele MS, Karataş Ayhan M, Derya S, Murat M, Gürbüz Ş, Yücel N.   +5 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Revisiting the foundation era of plant genomics with a commentary on the pioneering contributions of Prof. Chittaranjan Kole. [PDF]

Plant Genome
Nageswara-Rao M, Pandey S, Bhattacharjee P, Kumar Saini D, Soneji JR, Fakrudin B, Chandappa LH, Khoddamzadeh AA, Tucker DA, Zhang J, Eltaher S, Ali J, Henry R, Porth IM, Radanović A, Hori K, Dwiyanti MS, Branca F, Tiwari S, Blair M, Lim YP, Horn R, Danilevskaya O, Adhikari S.   +23 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Molecular architecture and spatial organization of proteasomes in the human sperm nucleus. [PDF]

Nat Struct Mol Biol
Kolata P, Dos Santos Á, Knowles O, Dendooven T, Allegretti M.   +4 more
europepmc   +1 more source