Results 161 to 170 of about 18,383,772 (292)
Keeping AI in medicine and radiology within the framework of scientific method: measuring to close the epistemic gap. [PDF]
Insights ImagingPesapane F, Sardanelli F.
europepmc +1 more source
Big data: the end of the scientific method? [PDF]
Philos Trans A Math Phys Eng Sci, 2019 Succi S, Coveney PV.
europepmc +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Instruction on the Scientific Method Provides (Some) Protection Against Illusions of Causality. [PDF]
Open Mind (Camb)Chow JYL +3 more
europepmc +1 more source
The clinical method is also scientific method
, 2013 The scientific method is a general method composed of several stages necessary for the development of any scientific research. It is the focus to approach reality and to study natural phenomenon, reality itself and thoughts in order to find their essence
Ovidio Díaz Valiente +2 more
core
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source