Results 31 to 40 of about 18,383,772 (292)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
What is Scientific Progress? Lessons from Scientific Practice [PDF]
, 2013 Alexander Bird argues for an epistemic account of scientific progress, whereas Darrell Rowbottom argues for a semantic account. Both appeal to intuitions about hypothetical cases in support of their accounts. Since the methodological significance of such
Mizrahi, Moti
core
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Strong inference in mathematical modeling: a method for robust science in the 21st century
Frontiers in Microbiology, 2016 While there are many opinions on what mathematical modeling in biology is, in essence, modeling is a mathematical tool, like a microscope, which allows consequences to logically follow from a set of assumptions.
Vitaly V. Ganusov +2 more
doaj +1 more source
Scientific realism and the history of science [PDF]
, 2005 The paper considers the two main challenges to scientific realism, stemming from confirmation holism and the underdetermination thesis as well as from semantic holism and the incommensurability thesis. Against the first challenge, it is argued that there
Esfeld, Michael
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Sociological implications of scientific publishing: Open access, science, society, democracy and the digital divide [PDF]
, 2010 Claims for open access are mostly underpinned with 1. science—related arguments (open access accelerates scientific communication); 2. financial arguments (open access relieves the serials crisis); 3.
Herb, Ulrich
core +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Solving initial-Value Problem of the First-Order Differential Equation by Euler’s Method using Casio fx 570EX Classwiz Scientific Calculator [PDF]
, 2018 Solving numerical methods manually without using a scientific calculator or using scientific calculator traditionally without input the iterative formula into the calculator can be quite tedious and boring due to its repetitive calculations. There is
Cheong, T. H, +2 more
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